This research was purposely to study and determine the physicochemical characteristics, sensory hypocholesterolemic effects of purple sweet potato bread made from flour, starch, fiber-rich flour starch processing waste on white male species Wistar rats conducted in vivo. used a non-factorial randomized block design model with treatment 100% standard feed, 25% mixture bread, combination 50% heal...

For 26 months, we fed baboons a high saturated fat, high cholesterol diet that contained very low concentrations of four common pesticides (chlordane, parathion, diazinon, and carbofuran). We detected no effect of pesticides on body weight, serum lipid, or lipoprotein cholesterol concentrations, or experimental atherosclerosis. We then examined the associations of serum lipid and lipoprotein ch...

The results of this study indicate that when human VLDL or LDL is prepared under conditions allowing oxidation, such oxidation renders the molecular complexes highly toxic to human skin fibroblasts growing in culture. The cytotoxicity can be predicted by assaying for the presence of thiobarbituric acid-reacting substances on the lipoprotein. However, malondialdehyde, which reacts with thiobarbi...

Disturbances of lipoprotein metabolism are recognized as indicators of cardiometabolic disease risk. Lipoprotein size and composition, measured in a lipoprotein profile, are considered to be disease risk markers. However, the measured profile is a collective result of complex metabolic interactions, which complicates the identification of changes in metabolism. In this study we aim to develop a...

HDLc, a cholesterol-rich lipoprotein that accumulates in the plasma of cholesterol-fed swine, was shown to resemble functionally human and swine low density lipoprotein in its ability to bind to the low density lipoprotein receptor in monolayers of cultured human fibroblasts. This binding occurred even though HDLc lacked detectable apoprotein B, which is the major protein of low density lipopro...

Excessive circulating triglycerides due to reduction or loss of lipoprotein lipase activity contribute to hypertriglyceridemia and increased risk for pancreatitis. The only gene therapy treatment for lipoprotein lipase deficiency decreases pancreatitis but minimally reduces hypertriglyceridemia. Synthesized in multiple tissues including striated muscle and adipose tissue, lipoprotein lipase is ...

Background: Familial chylomicronemia syndrome is a rare disorder of lipoprotein metabolism due to familial lipoprotein lipase or apolipoprotein C-II deficiency or the presence of inhibitors to lipoprotein lipase. It manifests as eruptive xanthomas, acute pancreatitis, and lipaemic plasma due to marked elevation of triglyceride and chylomicrons levels. Case presentation: We report a rare case of...

Lipoprotein lipase (LPL), the rate-limiting enzyme for hydrolysis of plasma lipoprotein triglycerides, is a normal constituent of the arterial wall. We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). When bovine milk LPL was added to endothelial cell monolayers before addition of ...

Freshly prepared rat testicular membranes bind iodinated rat high density lipoprotein (HDL) with high affinity (Kd = 32 microgram of HDL protein/ml). This high density lipoprotein binding differs from low density lipoprotein binding by cultured human fibroblast cells in two ways; it is not affected by Ca2+ or ethylenediaminetetraacetic acid, and it is not sensitive to pronase and trypsin. Testi...

We have carried out a cross-sectional multivariate analysis of serum and lipoprotein lipid levels in white persons from an industrial population. Very low density lipoprotein triglyceride level was independent of ethanol consumption but increased with adiposity and cigarette smoking and decreased with coffee-tea drinking. Concomitant age variation in indices of adiposity accounted for only a sm...