Tumor necrosis factor-alpha (TNF-alpha) stimulates lipolysis in human adipocytes. However, the mechanisms regulating this process are largely unknown. We demonstrate that TNF-alpha increases lipolysis in differentiated human adipocytes by activation of mitogen-activated protein kinase kinase (MEK), extracellular signal-related kinase (ERK), and elevation of intracellular cAMP. TNF-alpha activat...

A B S T RA C T Incubation of isolated rat epididymal fat cells is associated with the accumulation of adenosine in the incubation medium. To more clearly define the effect of adenosine on lipolysis, isolated rat epididymal adipocytes were studied with the perifusion system. Various combinations of epinephrine, adenosine, and adenosine deaminase were perifused through the adipocytes. Exogenous a...

The role of Ca2+ in adrenocorticotropic hormone (ACTH)stimulated lipolysis in rat adipocytes was investigated using perifused fat cells. With this system, it is possible to monitor minute-to-minute changes in glycerol release from adipocytes during both the activation and inactivation phases of hormone-induced lipolysis. The lipolytic response to ACTH was dose-dependent and 0.1 unit per ml of A...

We evaluated the effects of supplementation with DHEA (in elderly men and women) and testosterone (in elderly men) on postprandial or iv insulin suppression of lipolysis. We found no effect of these hormones on systemic lipolysis.

background: the burden of obesity and diet-related chronic diseases is increasing in iran, and prevention and treatment strategies are needed to address this problem. the aim of this study was to determine the outcome, cost, safety and cost-consequence of non-invasive weight loss interventions in iran.   methods: we performed a systematic review to compare non-invasive interventions (cryolipoly...

Lipolysis is an important metabolic pathway controlling energy homeostasis through degradation of triglycerides stored in lipid droplets and release of fatty acids. Lipid droplets of mammalian cells are coated with one or more members of the PAT protein family, which serve important functions in regulating lipolysis. In this study, we investigate the mechanisms by which PAT family members, peri...

Aerobic exercise increases whole body adipose tissue lipolysis, but is lipolysis higher in subcutaneous adipose tissue (SCAT) adjacent to contracting muscles than in SCAT adjacent to resting muscles? Ten healthy, overnight-fasted males performed one-legged knee extension exercise at 25% of maximal workload (W(max)) for 30 min followed by exercise at 55% W(max) for 120 min with the other leg and...

out influencing mechanical performance. The effects of norepinephrine on MV02 and on the size of ischemic injury after acute coronary occlusion were therefore studied before and during inhibition of lipolysis with P-pyridylcarbinol. In spite of similar mechanical responses to norepinephrine, MV02 increased by 57±11% before and significantly less, 31±6%, (P < 0.01) during inhibition of lipolysis...

Prostaglandin E(1) (PGE(1)) at a concentration of 1 ng/ml antagonized theophylline, and norepinephrine induced release of glycerol and free fatty acids (FFA) in human fat cell preparations. Insulin at higher doses also inhibited theophylline-stimulated lipolysis. The N(6)-2-0'dibutyryl derivative of cyclic adenosine monophosphate (DCAMP) stimulated lipolysis. Prostaglandin E(1) did not signific...

1 Sir: I view of recent United States Food and Drug Administration (USFDA) approval of deoxycholate (DC) as a constituent for lipolysis,1 we would like to share our experience of using it in combination with phosphatidylcholine (PC) for injection lipolysis. PC and DC have independently been used in lipolysis and are both USFDA approved; however, a combination of both has not been approved by th...