The present study was designed to explore the combined effects of a conventional antidiabetic drug, metformin (MET) and Gymnema sylvestre (GS) or Trigonella foenum graecum (TFG) extract in alloxan (ALX, 150 mg / kg body weight, IP)-induced swiss albino mice. Other than serum glucose, changes in total serum cholesterol (TC), triglyceride (TG), urea, α-amylase and alkaline phosphatase (ALP) level...

Behcet's disease (BD) is a chronic systemic inflammatory disease. Inflammatory reactions trigger the oxidative stress and oxidants decrease the level of antioxidants. In the present study, we aimed to determine serum oxidative/antioxidative status in patients with BD. Serum antioxidative status was evaluated by measuring total antioxidant capacity (TAC), paraoxonase 1, arylesterase, sulfhydryl ...

The importance of lipid peroxidation and its contributing pathways (via reactive oxygen species and lipoxygenase) during post-anoxia was evaluated with respect to the biphasic behavior of membrane lipids under anoxia (A. Rawyler, D. Pavelic, C. Gianinazzi, J. Oberson, R. Brändle [1999] Plant Physiol 120: 293-300), using potato (Solanum tuberosum cv Bintje) cell cultures. When anoxic cells in th...

Although lipid peroxidation associated with oxidative stress can result in cellular death, sub-lethal lipid peroxidation can gradually resolve with return to the pre-exposure state. We have shown that resolution of lipid peroxidation is greatly delayed in lungs or cells that are null for peroxiredoxin 6 (Prdx6) and that both the phospholipase A2 and the GSH peroxidase activities of Prdx6 are re...

In this thesis the effects of tocopherols and ascorbic acid on the formation and decomposition of methyl linoleate hydroperoxides (ML-OOH) were evaluated. The results contribute to the understanding of the antioxidant action of tocopherols and ascorbic acid during lipid oxidation reaction sequences. α-and γ-Tocopherols at 10-1000 ppm levels efficiently inhibited the formation of ML-OOH during t...

There is growing evidence that proteins are early targets of reactive oxygen species, and that the altered proteins can in turn damage other biomolecules. In this study, we measured the effects of proteins on the oxidation of liposome phospholipid membranes, and the formation of protein hydroperoxides in serum and in cultured cells exposed to radiation-generated hydroxyl free radicals. Lysozyme...