ll higher animals on this planet show some form of Asleep-like behavior, but still a consensus has not been reached on what determines the evolutionary value of sleep. Recent data suggest that one important aspect might be its role in the maintenance of energy homeostasis. Over the past decades, average daily sleep times have decreased by almost 20% in Western societies, in part caused by a lar...

Ecosystems are interactive systems involving communities of species and their abiotic environment. Tumors are ecosystems in which cancer cells act as invasive species interacting with native host cell species in an established microenvironment within the larger host biosphere. At its heart, to study ecology is to study interconnectedness. In ecologic science, an ecologic network is a representa...

Next-generation wireless networks should be able to coordinate and integrate different communication systems. It has been a challenging problem to support a seamless handover in these diverse wireless network environments. Link level triggers can provide information about events which can help handover decision and layer 3 entities better streamline their handover related activities. In most co...

Disruptions in circadian rhythms, as seen in human shift workers, are often associated with many health consequences including impairments in cognitive functions. However, the mechanisms underlying these affects are not well understood. The objective of the present study is to explore the effects of circadian disruption on hippocampal neurogenesis, which has been implicated in learning and memo...

Bridge-flocculated colloidal gels are used in many important processes and products such as gel casting for advanced ceramics, precursor inks for 3D printing, and waste treatment strategies. An important aspect of polymer bridged gels that makes them excellent candidates for these applications is the precise control it affords for control of rheological properties. Recent studies have shown tha...

Hypoxia-inducible factor (HIF), a key modulator of the transcriptional response to hypoxia, is increased in colon cancer. However, the role ofHIF in colon carcinogenesis in vivo remains unclear. In this study, we found that intestinal epithelium-specific disruption of the von Hippel–Lindau tumor suppressor protein (VHL) resulted in constitutive HIF signaling, and increased HIF expression augmen...

Disruption of the renal proximal tubule (PT) brush border is a prominent early event during ischemic injury to the kidney. The molecular basis for this event is unknown. Within the brush border, ezrin may normally link the cytoskeleton to the cell plasma membrane. Anoxia causes ezrin to dissociate from the cytoskeleton and also causes many cell proteins to become dephosphorylated in renal PTs. ...

Hypoxia-inducible factor (HIF), a key modulator of the transcriptional response to hypoxia, is increased in colon cancer. However, the role of HIF in colon carcinogenesis in vivo remains unclear. In this study, we found that intestinal epithelium-specific disruption of the von Hippel-Lindau tumor suppressor protein (VHL) resulted in constitutive HIF signaling, and increased HIF expression augme...

The synaptic localization, clustering, and immobilization of neurotransmitter receptors and ion channels play important roles in synapse formation and synaptic transmission. Although several proteins have been identified that interact with AMPA receptors and that may regulate their synaptic targeting, little is known about the interaction of AMPA receptors with the cytoskeleton. In studies exam...

Cyber-physical systems (CPSs) are emerging future engineered systems with combined efforts in cybernetics and advanced physical components. They are often designed for large and missioncritical systems, e.g., smart grids. The continuous availability of functionality is one of the important concerns by CPS stakeholders. Currently CPSs are still vulnerable to major disruptions. In this research w...