Polymethylmethacrylate (PMMA) impregnated with antibiotics is widely used in the treatment of osteomyelitis and infected arthroplasties. With the emergence of resistant bacterial strains, linezolid, which is active against gram-positive bacteria and toward which resistance has been scarce, has been suggested as an alternative. In the current in vitro study, the authors sought to determine and c...

BACKGROUND Linezolid is considered as a therapeutic alternative to the use of glycopeptides for the treatment of pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA). Clinical studies reported a potent survival advantage conferred by the oxazolidinone and called into question the use of glycopeptides as first-line therapy. METHODS In a mouse model of MRSA-induced pneumonia, ...

The aims of this multicentre open-label study was to evaluate the pharmacokinetics of linezolid in patients with burn injury above 20 % BSA and to compare them with healthy volunteers, matched in age, sex and weight. After a single 600 mg IV dose of linezolid, multiple blood and urine samples were taken from subjects, in order to determine linezolid concentrations, using a HPLC assay. C(max) an...

AIM This study describes the ocular pharmacokinetics of linezolid, an antibiotic with broad spectrum activity against those Gram positive bacteria that are the most frequent cause of postoperative endophthalmitis. METHOD Patients undergoing routine cataract surgery were given a single oral 600 mg dose of linezolid at a variable time before surgery. Aqueous and serum levels of linezolid were a...

Sir, To follow-up our previous finding of reduced polystyrene adherence accompanying the acquisition of linezolid resistance in a clinical bloodstream isolate of methicillin-resistant Staphylococcus aureus (MRSA), we evaluated the polystyrene adherence properties of linezolid-resistant staphylococci obtained from our institution as well as isolates obtained from multiple medical centres through...

In vitro activities of linezolid and vancomycin which were evaluated against methicill in resistant Staphylococcus aureus (MRSA). One hundred clinical isolates of MRSA were collected. The minimum inhibitory concentrations (MICs) of linezolid and vancomycin were determined by the Epsilon-test method. The results showed 100 percent susceptibility of linezolid and vancomycin against MRSA isolates....

1. There were satisfactory C max and C min only in Patient 2, whereas in Patient 1 there was an increased CL and reduced AUC. Since the PK/pharmacodynamic parameter of importance for linezolid activity is the AUC/MIC ratio, assessing changes in AUC exposure by body size is of paramount importance. 6 Only Patient 2 had satisfactory values of AUC and AUC/MIC. Furthermore, since linezolid PK is no...

OBJECTIVES Linezolid is a new oxazolidinone antibiotic with efficacy against a broad range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). In this study, we have determined the serum and sputum linezolid concentrations in adults with cystic fibrosis (CF) following oral drug administration. METHODS Eleven adult patients with CF were recruited. Subjects ...