نتایج جستجو برای: lincrna

تعداد نتایج: 344  

2017
Niedzica Camacho Peter Van Loo Sandra Edwards Jonathan D Kay Lucy Matthews Kerstin Haase Jeremy Clark Nening Dennis Sarah Thomas Barbara Kremeyer Jorge Zamora Adam P Butler Gunes Gundem Sue Merson Hayley Luxton Steve Hawkins Mohammed Ghori Luke Marsden Adam Lambert Katalin Karaszi Gill Pelvender Charlie E Massie Zsofia Kote-Jarai Keiran Raine David Jones William J Howat Steven Hazell Naomi Livni Cyril Fisher Christopher Ogden Pardeep Kumar Alan Thompson David Nicol Erik Mayer Tim Dudderidge Yongwei Yu Hongwei Zhang Nimish C Shah Vincent J Gnanapragasam William Isaacs Tapio Visakorpi Freddie Hamdy Dan Berney Clare Verrill Anne Y Warren David C Wedge Andrew G Lynch Christopher S Foster Yong Jie Lu G Steven Bova Hayley C Whitaker Ultan McDermott David E Neal Rosalind Eeles Colin S Cooper Daniel S Brewer

A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of the Knudson two hit genetic model in SCNA generation in prostate cancer. 64 recurrent regions of loss and gain were detected, of which 28 were novel,...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016
Fuqiang Wang Huili Yang Zhigang Deng Yongjie Su QinLiang Fang Zhenyu Yin

BACKGROUND Recent studies reveal that long non-coding RNAs (LncRNAs) play critical roles in the proliferation and migration of human cancer. Previous report has shown that LncRNA HOXA-AS2 was involved in carcinoma processes. However, the expression and biological function of HOXA-AS2 in hepatocellular carcinoma (HCC) are poorly understood. METHODS Quantitative real-time PCR (qRT-PCR) was perf...

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