PURPOSE To report our experience managing a limbal mass associated with limbal vernal keratoconjunctivitis (VKC) by surgical excision. METHODS A 16-year-old girl was referred to our hospital with the chief complaints of itching and photophobia in both eyes. She had a 2-year history of gradually enlarging limbal gelatinous masses on the temporal limbus in both eyes, which were diagnosed as lim...

The cornea is the outermost tissue of the eye and it must be transparent for the maintenance of good visual function. The superficial epithelium of the cornea, which is renewed continuously by corneal stem cells, plays a critical role in the permanence of this transparency. These stem cells are localized at the cornea-conjunctival transition zone, referred to as the limbus. When this zone is af...

BACKGROUND & OBJECTIVES Cultivated limbal stem cell transplantation is being used as a current treatment modality for limbal stem cell deficiency. However, use of allogenic biological material as substrate is associated with risks of transmission of certain diseases and allograft rejection. Therefore development of non-toxic biodegradable synthetic polymers is important. We undertook this study...

Limbal rings are dark annuli encircling the iris that fluctuate in visibility based on health and age. Research also indicates their presence augments facial attractiveness. Given individuals' prioritization of health cues in short-term mates, those with limbal rings may be implicated as ideal short-term mates. Three studies tested whether limbal rings serve as veridical health cues, specifical...

Severe ocular diseases may result in partial or complete limbal cell deficiency. Besides conservative options, treatment options include conjunctival replacement procedures and limbal autografting. Limbal allografts are an option in patients with bilateral limbal cell deficiency. In many of these cases, a keratoprosthesis (KPro) is the last option to restore functional vision in patients with s...

PURPOSE To investigate the phenotype of fetal and adult human limbal cells cultured on human amniotic membrane and the ability of cultured adult human limbal cells to repair limbal stem cell deficiency in a rabbit model. METHODS Human adult and fetal limbal cells were isolated and cultured either on plastic plates or on human amniotic membrane. Connexin43, p63, and keratins 3 and 12 (K3 and K...

BACKGROUND/AIM Chemical ocular burn, especially by alkali, may result in damage to the limbal stem cells, fundamental in maintaining the integrity of ocular surface. Clinically, patients manifest abnormal conjunctival-corneal healing with peripheral neovessels, chronic epithelial defect, severe stromal inflammation, and conjunctivalisation of the corneal, which is characteristic of limbal defic...

purpose: to compare clear corneal incision and scleral tunnel incision in terms of intraocular pressure (iop), post-operative inflammation, induced astigmatism, and corneal edema in phacoemulcification. methods: this non-controlled clinical trial was conducted on 78 eyes with senile cataract. a clear corneal incision was made in 40 eyes and a scleral tunnel incision was made in 38 eyes. all eye...

Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as vascularized conjunctivalization, keratinization, corneal scarring, and corneal opacification, collectively described as limbal stem cell deficiency (LSCD). Limbal stem cell deficiency may occur as a result of depletion of stem cells or destruction of their stromal niche. In such cases, apart from co...