نتایج جستجو برای: limb shaker
تعداد نتایج: 74044 فیلتر نتایج به سال:
Alkanols are small aliphatic compounds that inhibit voltage-gated K(+) (K(v)) channels through a yet unresolved gating mechanism. K(v) channels detect changes in the membrane potential with their voltage-sensing domains (VSDs) that reorient and generate a transient gating current. Both 1-Butanol (1-BuOH) and 1-Hexanol (1-HeOH) inhibited the ionic currents of the Shaker K(v) channel in a concent...
This second of three papers, in which we functionally characterize activation gating in Shaker potassium channels, focuses on the properties of a mutant channel (called V2), in which the leucine at position 382 (in the Shaker B sequence) is mutated to valine. The general properties of V2's ionic and gating currents are consistent with changes in late gating transitions, in particular, with V2 d...
0092-6566/$ see front matter 2013 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.jrp.2013.08.013 ⇑ Corresponding author. Address: Department of Psychology, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, United States. E-mail address: [email protected] (D.G. Serfass). 1 While a large body of research using Q-Sorts follows the procedure prescribed by Stephenson...
Maurotoxin (MTX) is a 34-mer scorpion toxin cross-linked by four disulphide bridges that acts on various K(+) channels, including the voltage-gated Shaker B subtype. In the present study, we have investigated over 80 h: (1) the time-course of folding of synthetic MTX (sMTX) by CD analysis; (2) the kinetics of disulphide bridge formation by MS; and (3) the potency of MTX in blocking Shaker B cur...
E.I. Ekwue 2 The design, construction and testing of a soil dry sieving apparatus, which could be used to effectively determine the particle size distribution curves of dry soil samples is described. The design required that a means be developed to agitate soil samples placed on two stacks of sieves, each arranged in decreasing sizes. The apparatus was designed to utilize a horizontal and verti...
Open-channel blockers such as tetraethylammonium (TEA) have a long history as probes of the permeation pathway of ion channels. High affinity blockade by extracellular TEA requires the presence of an aromatic amino acid at a position that sits at the external entrance of the permeation pathway (residue 449 in the eukaryotic voltage-gated potassium channel Shaker). We investigated whether a cati...
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