Objective(s): Although many researchers have confirmed induction of germ cells from bone marrow mesenchymal stem cells (BMMSCs), there are no reports that confirm spontaneous differentiation of germ cells from BMMSCs. In this study, we have evaluated the effect of adult Sertoli cell condition medium (SCCM) as a mutative factor in the induction of germ cells from BMMSCs. Materials and Methods: ...

Background: The role of mesenchymal stem cell in cellular therapy is the subject of interest for many researchers. The differentiation potential of MSCs and abilities in modulations of the recipient’s immune system makes them important cells in tissue regenerative studies. MSCs by releasing the proinflammatory cytokines play important role in immunomodulatory systems; however the signaling path...

Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK cells use inhibi...

Background and Aims: Mesenchymal stem cells (MSCs) are a preferred cell source for the generation of hepatocyte-like cells in regenerative medicine. They can be isolated from different sources, including adipose tissues. The Raman spectroscopy approach was evaluated for quick and efficient identification of MSCs differentiation status and a broader perspective on cell differentiation. Material...

Microtubule Affinity-Regulating Kinase 2 (MARK2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. The abnormal function of this protein has been associated with a number of pathological conditions like Alzheimer disease, autism, several carcinomas and development of...

introduction: radiation induced bystander effect (ribe) which cause radiation effects in non-irradiated cells, has challenged the principle according to which radiation traversal through the nucleus of a cell is necessary for producing biological responses. what is the mechanism of this phenomenon? to have a better understanding of this rather ambiguous concept substantial number of original an...

Two new algal species, namely, Prasiola calophylla (Prasiolaceae), and Closterium navicula (Closteriaceae) were collected from west coasts of the Caspian sea (Mazandaran province, N Iran), and runoff in south Tehran, respectively. Both the species were analyzed on the bases of morphological and anatomical characters and were determined using identification keys and interspecific comparison. Pra...

peripheral t-cell lymphomas are a group of heterogeneous disorders and according to who classification, are categorized into nodal and extranodal forms. nk/t-cell lymphoma, nasal type, is a subtype of extranodal peripheral t-cell lymphoma and commonly presents as a midfacial destructive lesion. this disorder is more prevalent in asia and south america and has a strong association with epstein b...