BACKGROUND The pathophysiological mechanisms leading to acceleration of ventricular tachycardia (VT) are still unclear. METHODS AND RESULTS High-resolution epicardial mapping was used to study the mechanisms of VT acceleration by programmed electrical stimulation (PES) in a model of sustained reentrant VT in Langendorff-perfused rabbit hearts (n = 40). Three different mechanisms responsible f...

BACKGROUND Knowledge of cycle-to-cycle changes in isthmus geometry is of potential importance for radiofrequency catheter ablation to stop reentrant ventricular tachycardia. It was hypothesized that isthmus geometry often undergoes continuous evolution throughout reentry and that cycle-length variability measurements could be used to segment reentry into distinct phases and to predict changes i...

Cardiac fibrosis is a well-known arrhythmogenic condition which can lead to sudden cardiac death. Physically, be viewed as large number of small obstacles in an excitable medium, may create nonlinear wave turbulence or reentry. The relation between the specific texture and onset reentry great theoretical practical importance. Here, we present conceptual framework combines functional aspects pro...

Ten young male participants were recruited to test their maximum symmetric and asymmetric isoinertial lifting capabilities from floor to the knuckle height in different container dimensions varied in both width and length. The results showed that the order from the highest to lowest lifting capability for the lifting modes was symmetric lifting, asymmetric lifting with leg rotation and asymmetr...

The importance of activation sequence of an atrioventricular junctional reentrant (AVJRe) circuit, before delivery of an extrastimulus, has received little attention in studies concerned with clinical tachycardias. In this study a change in activation sequence was accomplished using bidirectional activation (V-A sequential pacing) during the basic drive (V1A1-V1A1). It was noted that, compared ...

curves on atrial extrastimulus testing. Stimulation was performed from the right atrium in all cases. The left atrium was stimulated from the coronary sinus in 13 patients and directly through a patent foramen ovale in two patients. Baseline fast-AVN-pathway AH intervals were significantly shorter with left atrial stimulation. Maximum AH intervals for conduction over the fast or slow AVN pathwa...

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any age but is very rare in children and becomes extremely common in the elderly, with a prevalence approaching 20% in patients 85 years of age.1 AF is associated with a wide range of potential complications and contributes significantly to population morbidity and mortality. Present therapeutic approac...

BACKGROUND Phase 2 reentry caused by heterogeneous loss of the transient outward potassium current (I(to))-mediated epicardial action potential (AP) dome can produce a closely coupled R-on-T extrasystole leading to ventricular fibrillation (VF) under conditions of ST-segment elevation unrelated to ischemia. The present study examined the role of phase 2 reentry in the initiation of VF during ea...