The actin depolymerizing factor (ADF)/cofilin protein family is essential for actin dynamics, cell division, chemotaxis and tumor metastasis. Cofilin-1 (CFL-1) is a primary non-muscle isoform of the ADF/cofilin protein family accelerating the actin filamental turnover in vitro and in vivo. In response to environmental stimulation, CFL-1 enters the nucleus to regulate the actin dynamics. Althoug...

Lewis, Peter (2016). Improving peripheral vision through optical correction and stimulus motion. Linnaeus University Dissertation No 248/2016, ISBN: 978-9188357-14-4. Written in English. The loss of central vision subsequent to macular disease is often extremely debilitating. People with central field loss (CFL) must use other peripheral areas of the retina in order to see; areas with inferior ...

BACKGROUND Diagnostic criteria for dementia with Lewy bodies (DLB) are still evolving. No data exist on prospective differentiation of DLB and Alzheimer disease (AD). OBJECTIVE To examine the clinician's diagnostic accuracy for DLB and analyze factors contributing to false-positive DLB diagnoses. METHODS A prospective series of 10 patients with clinically diagnosed DLB who came to autopsy w...

1.1 Dementia with Lewy bodies: An overview Dementia with Lewy bodies (DLB) is a progressive neurodegenerative disorder characterized by the core clinical features of fluctuating consciousness, visual hallucinations and parkinsonism. The term DLB and the clinical criteria were first introduced and proposed by Mc Keith and colleagues in 1996 during the First International Workshop of the Consorti...

The advance in research on the dementia syndrome associated with Parkinson's disease recently gains momentum in part because Parkinson's disease inevitably causes declined cognition and then lead to poor quality of life. More importantly, dementia of Lewy bodies, now known as the second most common neurodegenerative disorder, shares the common neuropathological hallmark with Parkinson's disease...

In this study, a biomimetic microfluidic plasma separation device is discussed. The design of the device drew inspiration from in vivo observations of enhanced cell-free layer (CFL) formation downstream of vascular bifurcations. The working principle for the plasma separation was based on the plasma skimming effect in an arteriolar bifurcation, which is modulated by CFL formation. The enhanceme...

Conventional explicit nite diierence schemes for the advection equations are subject to the time step restrictions dictated by the CFL condition. In many situations, time step sizes are not chosen to satisfy accuracy requirements but rather to satisfy the CFL condition. In this paper we present explicit algorithms which are stable far beyond the CFL restriction. Similar or even better accuracy ...

Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino-terminal and carboxyl-termin...

BACKGROUND (123)I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease. AIMS Our aim was to determine the accuracy of (123)I-FP-CIT SPECT in diagnosing people with possible dementia with Lewy bodies. METHOD We undertook a 12-month follow-up of 325 individuals with p...

C57BU10 (BlO; H2b ) mouse liver grafts are accepted in C3R (H2k) recipients without immunosuppressive tberapywhereas skin and heart grafts are rejected acutely.1 However, in vitro mixed leukocyte reactions (MLR) and the generation of cytotoxic T lymphocytes (crL) show the persistence of anti-donor responsiveness.2 The mechanism underlying this "split tolerance" phenomenon is unclear. The presen...