BACKGROUND Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is maximized and all states of motor action are trapped with consequently high heterogeneity. This heterogeneity is a major limitation to deciphering myosin conformational changes in situ. METHODOLOGY We used multivariate data ana...

OBJECTIVE To test the hypothesis that a custom-fit valgus knee brace and custom-made lateral wedge foot orthotic will have greatest effects on decreasing the external knee adduction moment during gait when used concurrently. DESIGN Proof-of-concept, single test session, crossover trial. SETTING Biomechanics laboratory within a tertiary care center. PARTICIPANTS Patients (n=16) with varus ...

Myosin motors in cardiac ventriculum convert ATP free energy to the work of moving blood volume under pressure. The actin bound motor cyclically rotates its lever-arm/light-chain complex linking motor generated torque to the myosin filament backbone and translating actin against resisting force. Previous research showed that the unloaded in vitro motor is described with high precision by single...

Abstract In this study, a light weight portable manual food grinder for domestic use was designed and fabricated to meet grinding needs that arise from erratic power supply in Nigeria. The design analysis crank lever parameters conveyor shaft diameter were done. To make the weight, body of machine, front cover house mechanisms support stand printed with Fused deposition modelling 3D printer. le...

For the Inertial Navigation System (INS) in hypersonic flight, when centroid of Measurement Unit (IMU) does not coincide with that vehicle, a lever-arm effect error will be generated, which further expand dynamic complex environment. In order to improve navigation accuracy, needs compensated. Although much research has been done on compensation effect, existing methods are almost based fixed le...