BACKGROUND A better description of the clinical and laboratory manifestations of fatal patients with dengue hemorrhagic fever (DHF) is important in alerting clinicians of severe dengue and improving management. METHODS AND FINDINGS Of 309 adults with DHF, 10 fatal patients and 299 survivors (controls) were retrospectively analyzed. Regarding causes of fatality, massive gastrointestinal (GI) b...

AND MARIO STEFANINI, sI.D.t H EMATOLOGIC CHANGES following the subcutaneous injection of epinephrin were first described by Loeper and Crouzon in 1903.’ Leukocytosis of varying degrees after parenteral administration of epmephrin has since been regularly observed by all investigators.28 Epinephrin-induced leukocytosis appears to occur in two distinct phases: (1) an early phase, due mainly to an...

T HE earlier studies of the writer have demonstrated that the leukocytosis accompanying many inflammatory processes is referable to the liberation at the site of inflammation of a factor closely associated with the pseudoglobulin fraction of ‘ ‘ 2 , 3 The factor per se offers a reasonable explanation for the mechanism of leukocytosis with inflammation. This factor not only induces a discharge o...

Few modern studies have enumerated the conditions associated with leukocytosis. Our clinical experience has implicated Clostridium difficile infection in a substantial proportion of patients with leukocytosis. In a prospective, observational study of 400 inpatients with WBC counts of >/=15,000 cells/mm(3), we documented >/=1 infection in 207 patients (53%). Of these 207 patients, 97 (47%) had p...

Leukocytes contribute to the pathogenesis of thrombosis in essential thrombocythemia (ET) through recently discovered mechanisms of activation and interaction with platelets and endothelial cells. To evaluate whether an increased leukocyte count was associated with thrombosis and whether this effect can be modulated by therapy, we analyzed the clinical course of 439 patients with ET followed at...

Studies were performed on a teen-age female identical twin with cyclic leukocytosis and Ph’-positive chronic myelogenous leukemia (CML), in an attempt to analyze the relationship of these cycles to her disease and to utilize the cycles as reference points for kinetic studies and as landmarks in the progression of her disease. She remained untreated for 2V2 yr. Colony-stimulating factor levels s...

Background: The aim of the present study was to investigate any prognostic value of pre-treatment anemia, leukocytosis and thrombocytosis in patients with advanced pretreated NSCLC. Methods: A randomized, multicenter phase II study comparing the IGF-1R modulator AXL with standard docetaxel in the treatment of previously treated stage IIIB or IV NSCLC patients was conducted in 2011-2013. Clinica...