نتایج جستجو برای: leukocyte telomere length

تعداد نتایج: 346584  

Journal: :Journal of Cognitive-Behavioral Psychotherapy and Research 2017

2014
Jason Y. Y. Wong Immaculata De Vivo Xihong Lin Shona C. Fang David C. Christiani

BACKGROUND Chronic inflammation from recurring trauma is an underlying pathophysiological basis of numerous diseases. Furthermore, it may result in cell death, scarring, fibrosis, and loss of tissue function. In states of inflammation, subsequent increases in oxidative stress and cellular division may lead to the accelerated erosion of telomeres, crucial genomic structures which protect chromos...

2010
Karen A Mather Anthony F Jorm Kaarin J Anstey Peter J Milburn Simon Easteal Helen Christensen

BACKGROUND Cognitive function and telomere length both decline with age. A correlation between these two measures would suggest that they may be influenced by the same underlying age-related biological process. Several studies suggest telomere length may be positively correlated with cognitive performance but the evidence is equivocal. In this report, the relationships between telomere length a...

2017
Andrew Steptoe Mark Hamer Jue Lin Elizabeth H. Blackburn Jorge D. Erusalimsky

Context Chronic psychological stress has been associated with shorter telomeres, but the underlying mechanisms are poorly understood. One possibility is that the neuroendocrine responses to stress exposure are involved. Objective To test the hypothesis that greater cortisol responsivity to acute stressors predicts more rapid telomere attrition. Design We measured salivary cortisol responses...

Journal: :Health & place 2014
Belinda L Needham Judith E Carroll Ana V Diez Roux Annette L Fitzpatrick Kari Moore Teresa E Seeman

Telomeres are the protective caps at the ends of eukaryotic chromosomes. Telomeres get shorter each time a cell divides, and critically shortened telomeres trigger cellular senescence. Thus, telomere length is hypothesized to be a biological marker of aging. The purpose of this study was to examine the association between neighborhood characteristics and leukocyte telomere length. Using data fr...

Journal: :Journal of clinical and diagnostic research : JCDR 2015
Dirk de Beer Jan Völzmann Christoph Kalka Gabriela M Baerlocher

Telomere attrition has been linked to accelerate vascular ageing and seems to predispose for vascular disease. Our aim was to study the telomere length dynamics over time and in subsets of leukocytes from 15 patients with peripheral arterial disease (PAD). The mean telomere length in subsets of leukocytes of patients with PAD was in the normal range of age-related telomere length values from he...

2014
Mark M. Iles D. Timothy Bishop John C. Taylor Nicholas K. Hayward Myriam Brossard Anne E. Cust Alison M. Dunning Jeffrey E. Lee Eric K. Moses Lars A. Akslen Per A. Andresen Marie-Françoise Avril Esther Azizi Giovanna Bianchi Scarrà Kevin M. Brown Tadeusz Dębniak David E. Elder Eitan Friedman Paola Ghiorzo Elizabeth M. Gillanders Alisa M. Goldstein Nelleke A. Gruis Johan Hansson Mark Harland Per Helsing Marko Hočevar Veronica Höiom Christian Ingvar Peter A. Kanetsky Maria Teresa Landi Julie Lang G. Mark Lathrop Jan Lubiński Rona M. Mackie Nicholas G. Martin Anders Molven Grant W. Montgomery Srdjan Novaković Håkan Olsson Susana Puig Joan Anton Puig-Butille Graham L. Radford-Smith Juliette Randerson-Moor Nienke van der Stoep Remco van Doorn David C. Whiteman Stuart MacGregor Karen A. Pooley Sarah V. Ward Graham J. Mann Christopher I. Amos Paul D. P. Pharoah Florence Demenais Matthew H. Law Julia A. Newton Bishop Jennifer H. Barrett

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sid...

Journal: :American journal of public health 2014
Cindy W Leung Barbara A Laraia Belinda L Needham David H Rehkopf Nancy E Adler Jue Lin Elizabeth H Blackburn Elissa S Epel

OBJECTIVES We tested whether leukocyte telomere length maintenance, which underlies healthy cellular aging, provides a link between sugar-sweetened beverage (SSB) consumption and the risk of cardiometabolic disease. METHODS We examined cross-sectional associations between the consumption of SSBs, diet soda, and fruit juice and telomere length in a nationally representative sample of healthy a...

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