There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

Abstract Stereotyped B-cell receptors (BCR) are frequent in patients with chronic lymphocytic leukemia (CLL). In cell culture and mouse models of CLL, immunogenic epitopes these BCRs were shown to trigger specific T-cell responses control development. These results suggest vaccination autologous BCR-derived peptides as a novel therapy for CLL. See related article by Rovida et al., p. 729

Introduction. Extramedullary sites of leukemic proliferation, harboring an adverse outcome, are rare and usually found in the blastic phase chronic myeloid leukemia. We report a case newly diagnosed patient with leukemia phase, infiltration right ovary on disease presentation. Case report. The presented abdominal pain, leukocytosis, anemia. A peripheral blood smear indicated leukemia, cytoreduc...

background: leukemia is a malignant proliferative disorder of the hematopoietic cells. the important role of angiogenesis in leukemia has been reported by several studies. matrix metalloproteinases (mmps) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. objective: the present study was conducted to evaluate the patterns of ...

Background: Leukemia is a malignant proliferative disorder of the hematopoietic cells. The important role of angiogenesis in leukemia has been reported by several studies. Matrix metalloproteinases (MMPs) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. Objective: The present study was conducted to evaluate the patterns of ...

stem cells are undifferentiated cells with the ability of proliferation, regeneration, conversion to differentiated cells and producing various tissues. stem cells are divided into two categories of embryonic and adult. in another categorization stem cells are divided to totipotent, multipotent and unipotent cells. so far usage of stem cells in treatment of various blood diseases has been studi...

conclusions to our knowledge, this is the first chronic case confirmed by the prolonged presence of hev rna in china. it is also the first reported persistent hepatitis e infection caused by hev genotype 4. case presentation here we report a chinese boy with acute lymphoblastic leukemia, who developed hepatitis e during a period of intensive chemotherapy. twenty months after the initial infecti...

background: for adult all patients, the indications and appropriate timing of allogeneic hematopoietic stem cell transplantation (ahsct) continue to be debated. the primary aim of this single-institution study was to compare the results of our adult all patients that had been allografted with those reported in the current literature. subjects and methods: this study included 53 consecutive adul...

Background: Scatter grams-graphic depictions of the cell populations in a blood sample are produced by automated analyzers. These scatter grams can be employed to screen for various hematological conditions, including anemia, leukemia, and other disorders examining gram’s population distribution patterning. Aims Objectives: In this study, we wish study generated Sysmex XN-series analyzer confir...

Background: Cancer is a public health emergency. It has a high mortality rate despite numerous studies on pharmaceutical therapies. Chimeric antigen receptor-natural killer (CAR-NK) cells are promising immunotherapy that could be used to treat cancer, especially leukemia. However, the evidence is still unclear. Thus, this systematic review aims to summarize the evidence regarding the use of CAR...