Background Letrozole is an aromatase inhibitor which can decrease estrogen production in peripheral tissues and endometriosis. Danazol, as an androgen, inhibits estrogen production in ovaries and recently has been introduced as an aromatase inhibitor. This study was designed to compare the effects of Danazol with Letrozole on endometriosis symptom relief. MaterialsAndMethods This study was a ra...

BACKGROUND Estrogen causes proliferation of ovarian cancer cells. Although hormone therapy with an anti-estrogen agent is an optional therapy for recurrent epithelial ovarian cancers, both basic and clinical researches are insufficient. We here examine the efficacy of an aromatase inhibitor (AI) for peritonitis carcinomatosa, the late stage of ovarian cancer. METHODS Estrogen receptor (ER)α w...

We tested the hypothesis that letrozole increases sperm count in non-obstructive azoospermic or cryptozoospermic patients with a testosterone (T)/17-beta-2-oestradiol (E2) ratio <10. Forty-six patients with no chromosomal aberrations were randomized into two groups: 22 received letrozole 2.5 mg per day for 6 months (Group 1: 6 azoospermic + 16 cryptozoospermic patients), while 24 received a pla...

background: the objective of this prospective randomized study was to make a comparison between the effects of letrozole and tamoxifen (tmx) in ovulation induction in clomiphene (cc)-resistant women with polycystic ovarian syndrome (pcos). methods: the study comprised a total of 60 infertile women (180 cycles) with cc-resistant pcos selected from the clinics affiliated to the department of obst...

OBJECTIVE To compare the effect of letrozole with combined metformin and clomiphene citrate (CC) for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS). DESIGN A randomized controlled trial. SETTING University teaching hospital and a private practice setting. PATIENT(S) Two hundred fifty anovulatory women (582 cycles) with CC-resistant PCOS. INTERVENTION(S) ...

Background: We performed this study to investigate and compare the effects of Letrozole and gonadotrophins versus Clomiphene Citrate and gonadotrophins in women undergoing superovulation for Intrauterine Insemination (IUI). Methods: We performed this prospective cohort study at Australian Concept and Fertility centre, Karachi Pakistan. Women younger than 40 years of age with patent fallopian tu...

BACKGROUND Poor ovarian response to controlled ovarian stimulation is one of the most important interest points in assisted reproduction. Mild ovarian stimulation seems to be preferable to high dose of FSH regimens in women with a history of poor ovarian response in previous protocol. Clomiphene citrate and letrozole alone or in combination with FSH have been used in mild ovarian stimulation pr...

The aim of the present study was to compare the reproductive outcomes of letrozole and laparoscopic ovarian drilling (LOD) in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). A total of 141 women with CC-resistant PCOS were enrolled and randomly allocated into groups A and B. Group A (n=71) received 2.5 mg letrozole from days 5 to 10 of menses for up to six cycles,...

OBJECTIVES To compare endometrial thickness following augmentation of ovulation with clomifene (CC) and letrozole and to assess the rate of multi-follicle development and the FSH fluctuations during the stimulated cycles. METHODS A comparative study was carried out at the infertility clinic of Faculty of Medicine, University of Kelaniya, Sri Lanka. Each arm included 25 participants. They rece...

PURPOSE The main objectives of this phase I and pharmacokinetic, open-label study were to determine the optimally tolerated regimen (OTR), safety, pharmacokinetics, and clinical activity of lapatinib in combination with letrozole in patients with advanced solid malignancies. EXPERIMENTAL DESIGN Patients with advanced breast cancer with immunohistochemically detectable estrogen or progesterone...