The beta-globin locus control region (LCR) is contained on a 20 kb DNA fragment and is characterized by the presence of five DNaseI hypersensitive sites in erythroid cells, termed 5'HS1-5. A fully active 6.5 kb version of the LCR, called the muLCR, has been described. Expression of the beta-like globin genes is absolutely dependent on the presence of the LCR. The developmental expression patter...

The Locus Control Region (LCR) requires intronic elements within beta-globin transgenes to direct high level expression at all ectopic integration sites. However, these essential intronic elements cannot be transmitted through retrovirus vectors and their deletion may compromise the therapeutic potential for gene therapy. Here, we systematically regenerate functional beta-globin intron 2 elemen...

THYFAULT, J.P. and E.M. MORRIS. Intrinsic (genetic) aerobic fitness impacts susceptibility for metabolic disease. Exerc. Sport Sci. Rev., Vol. 45, No. 1, pp. 7–15, 2017. Low-capacity runner (LCR) and high-capacity runner (HCR) rat strains are divergent for running capacity and aerobic fitness. The LCR rats are susceptible to obesity, insulin resistance, and fatty liver whereas the HCR are prote...

In this paper, the performance of average level crossing rate (LCR) and average fade duration (AFD) of the output signal of the maximum ratio combining (MRC) and the selection combining (SC) with a dual-branch receiver was analyzed. We derived some of the expressions with average LCR and AFD for both MRC and SC schemes operating in the correlated fading channel. The channel model of the diversi...

This paper aims to examine drivers of Liquidity coverage ratio (LCR) in Croatia. The intention this study is and analyse the effect Return on Equity (ROE), Non-performing Loans (NPL), Gross domestic product (GDP) Coverage Ratio Croatian banking sector. population sector from q3 2016 2021. Empirical results suggested real GDP growth rates NPL levels as LCR Croatia while effects ROE were not empi...

Fatty liver has been linked to low aerobic fitness, but the mechanisms are unknown. We previously reported a novel model in which rats were artificially selected to be high capacity runners (HCR) and low capacity runners (LCR) that in a sedentary condition have robustly different intrinsic aerobic capacities. We utilized sedentary HCR/LCR rats (generation 17; max running distance equalled 1514 ...

The cholinergic antiinflammatory pathway (CAP), which terminates in the spleen, attenuates postoperative cognitive decline (PCD) in rodents. Surgical patients with metabolic syndrome exhibit exaggerated and persistent PCD that is reproduced in postoperative rats selectively bred for easy fatigability and that contain all features of metabolic syndrome (low-capacity runners [LCRs]). We compared ...

Previous studies found that selection for endurance running in untrained rats produced distinct high (HCR) and low (LCR) capacity runners. Furthermore, despite weighing 14% less, 7th generation HCR rats achieved the same absolute maximal oxygen consumption (Vo(2max)) as LCR due to muscle adaptations that improved oxygen extraction and use. However, there were no differences in cardiopulmonary f...

Low-intrinsic aerobic capacity is associated with increased risk for cardiovascular and metabolic diseases and is a strong predictor of early mortality. The effects of intrinsic aerobic capacity on the vascular response to insulin are largely unknown. We tested the hypothesis that rats selectively bred for a low capacity to run (LCR) exhibit vascular dysfunction and impaired vascular reactivity...

We provide an analytical approach for the evaluation of important second order statistical parameters, as level crossing rate (LCR) and average outage duration (AOD) of MRC combiner in Log-Normal shadowed channels. New expressions have been derived for LCR and AOD in closed form. The results are valid for an arbitrary number of independent identically distributed diversity branches in the prese...