BACKGROUND Despite extensive data examining perioperative risk in patients with coronary artery disease, little attention has been devoted to the implications of conduction system abnormalities. OBJECTIVE To define the clinical significance of bundle-branch block (BBB) as a perioperative risk factor. METHODS Retrospective, cohort-controlled study of all noncardiac, nonophthalmologic, adult ...

AIMS Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs. METHODS AND RESULTS Clinical variables and outcomes after a median follow-up...

To assess whether gross pathologic differences exist between hearts with left bundle branch block (LBBB) and left-axis deviation (LAXD) and those with LBBB and a normal frontal plane axis, we examined 70 hearts with LBBB in a series of 1410 sequential dissections (5%). Thirty-two hearts had LAXD and 34 had normal axes on the correlative ECG. Left ventricular enlargement occurred frequently (93%...

Background Left bundle branch block (LBBB) is a condition associated with increased mortality and poor prognosis, depending on the underlying etiology. Identification of the etiology and appropriate risk stratification of patients with LBBB is a challenge, despite the availability of various testing modalities. Nuclear exercise stress testing can show artificial perfusion defects in the interve...

Background Echocardiographic studies have shown a reduction in global left ventricular (LV) ejection fraction (LVEF) in patients with isolated left bundle branch block (LBBB). This is likely due to altered electromechanical activation and resultant loss of septal contribution to LV systolic function. We sought to characterize LV volumes and global systolic function in adult subjects with an iso...

OBJECTIVES To assess cardiac electrical activation by using body surface potential mapping (BSPM), in patients with congestive heart failure (CHF) and left bundle branch block (LBBB) undergoing cardiac resynchronization therapy (CRT) with biventricular pacemaker (BIV-PM) implantation. METHODS Mean cardiac electrical activation times were analyzed in the right ventricle (RV) (mean RV activatio...

BACKGROUND We aimed to investigate the cardiac effects of left bundle-branch block (LBBB) using myocardial contrast echocardiography (MCE) to ascertain the value of MCE for detecting coronary artery disease (CAD) and to uncover the mechanism that affects the accuracy of single-photon emission computed tomography (SPECT) in these patients. METHODS AND RESULTS Sixty-three symptomatic LBBB patie...

OBJECTIVES The aim of this study was to identify resting measurements of left ventricular (LV) function that predict exercise capacity in dilated cardiomyopathy (DCM); in particular, the effects of left bundle branch block (LBBB), coronary artery disease (CAD), and total isovolumic time (t-IVT). BACKGROUND The t-IVT is a major determinant of cardiac output during dobutamine stress in DCM, and...

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Research Foundation Flanders (FWO). Introduction Septal strain patterns measured by echocardiography reflect the gradual process left bundle branch block (LBBB)-induced ventricular (LV) remodeling. We investigated whether these stages also predict progressive volumetric response and outcome in cardiac resynch...