background: changes in body composition may be used for monitoring progression/ regression of a disease. prompt γ-rays in vivo neutron activation analysis (ivnaa) has been widely used for the measurement of body composition in recent years. objective: in this paper, we tried to improve the safety of ivnaa operator. methods: the most important factor for reducing the operator receiving dose is t...

We experimentally evaluated the proton beam dose reproducibility, sensitivity, angular dependence and depth-dose relationships for a new Metal Oxide Semiconductor Field Effect Transistor (MOSFET) detector. The detector was fabricated with a thinner oxide layer and was operated at high-bias voltages. In order to accurately measure dose distributions, we developed a practical method for correctin...

PURPOSE We have developed an accurate dose calculation model based on a simplified Monte Carlo (SMC) method adapted to a beam-wobbling delivery system at National Cancer Center Hospital East (NCCHE). We used an initial beam model specific to the beam-wobbling system to reproduce accurately different dose distributions in two lateral directions (x- and y-directions) perpendicular to each other. ...

The use of electronic portal imaging devices (EPIDs) is a promising method for the dosimetric verification of external beam, megavoltage radiation therapy-both pretreatment and in vivo. In this study, a previously developed EPID back-projection algorithm was modified for IMRT techniques and applied to an amorphous silicon EPID. By using this back-projection algorithm, two-dimensional dose distr...

The purpose was to identify an optimal set of treatment planning parameters and a minimal necessary dose matrix resolution for treatment planning with spot-scanned protons. Treatment plans based on different combinations of planning parameters and dose grid resolutions (DG) were calculated in a homogeneous geometric phantom for three cubic targets of different size: 8, 64 and 244 cm3. The proto...

The lateral habenula (LHb) plays an important role in learning driven by negative outcomes. Many drugs of abuse, including ethanol, have dose-dependent aversive effects that act to limit intake of the drug. However, the role of the LHb in regulating ethanol intake is unknown. In the present study, we compared voluntary ethanol consumption and self-administration, yohimbine-induced reinstatement...

PURPOSE Noninvasive image-guided breast brachytherapy delivers conformal HDR (192)Ir brachytherapy treatments with the breast compressed, and treated in the cranial-caudal and medial-lateral directions. This technique subjects breast tissue to extreme deformations not observed for other disease sites. Given that, commercially-available software for deformable image registration cannot accuratel...

Purpose: To investigate the dosimetric differences between colpostats and cylinder applicators for intravaginal brachytherapy. Methods and Materials: Dose distributions near vaginal colpostats and dome cylinders were computed with a commercial high–dose-rate treatment-planning system and verified by spot measurements by using LiF thermoluminescent dosimeters. Taking source anisotropy into a...