primary colorectal lymphoma (pcl) is a rare condition that accounts for a small percentage of all gastrointestinal (gi) malignancies. there are several reports in the literature regarding the most common features of pcl. however, primary lymphoma in the rectosigmoid junction has been rarely reported. our case was a 67-year-old male who presented with non-specific symptoms of bowel obstruction w...

introduction: most b-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. molecular techniques can be used as a helpful diagnostic tool in these cases. in this study, we assessed the value of polymerase chain reaction (pcr) t...

primary hepatic lymphoma (phl) is rare and possibly associated with viral hepatitis and autoimmune diseases. scleroderma could exceptionally be complicated by lymphoma. we describe phl occurring in a 52-year-old female suffering scleroderma for eight years, with no history of cytotoxic or high-dose glucocorticoid therapy. ct scan, performed to work-up abdominal discomfort, constipation, and ele...

Rituximab has greatly improved standard cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but prospects remain poor in patients with adverse risk factors. We need to know whether the addition of rituximab also improves the efficacy of more intensive treatments and how to use molecular profiling to guide us in introducing other novel agents.