Vascular calcification (VC) is frequent prevalence in patients with chronic kidney disease (CKD) and atherosclerosis. Lanthanum carbonate is used as an orally administered phosphate-binding agent to reduce the gastrointestinal absorption of phosphate and ameliorate VC in advanced CKD. In this study, we used bovine vascular smooth muscle cells as a model VC in vitro and studied the effects of la...

The effects of PA21, a novel iron-based and non-calcium-based phosphate binder, on hyperphosphatemia and its accompanying bone abnormality in chronic kidney disease-mineral and bone disorder (CKD-MBD) were evaluated. Rats with adenine-induced chronic renal failure (CRF) were prepared by feeding them an adenine-containing diet for four weeks. They were also freely fed a diet that contained PA21 ...

BACKGROUND Despite recognized risks associated with hyperphosphataemia in patients with chronic kidney disease (CKD) Stage 5 on dialysis, the achievement of target levels of serum phosphate is poor. It is likely that this is partly due to poor adherence by patients to their phosphate-binder treatment regimens, which often comprise large daily tablet burdens. METHODS In this multicentre, open-...

The effects of extracellular phosphate and lanthanum on cytosolic free Ca2+ [( Ca2+]i) levels were studied in isolated rat pancreatic acini. In the presence of 1.28 mM Ca2+ and 1.0 mM phosphate, the mean resting [Ca2+]i level was 120 nM. Omission of phosphate from incubation medium significantly lowered this value to 94 nM. The gastrointestinal hormone cholecystokinin octapeptide (CCK-8) rapidl...

a pvc membrane electrode based on 1-[({[(butylsulfunyl)carbothioyl]disulfanyl} carbothioyl)sulfanyl]butane as a suitable ion carrier for determination of lanthanum(iii) ion was prepared. this electrode revealedsuch a good selectivity toward la3+ ion over a wide variety of other metal ions. some experimental parametersuch as membrane composition, nature, and amount of plasticizer, the amount of ...

Andrew F. May,1 Jean-Pierre Fleurial,2 and G. Jeffrey Snyder3 1Department of Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA 2Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California 91109, USA 3Department of Materials Science, California Institute of Technology, 1200 East ...

C₈₀ is a fullerene species which appears in different isomeric configurations. A general homodesmotic reaction previously designed to study the energy of fullerenes was implemented, in order to analyze the energy of this family of isomers. These results concur with some of the experimental data, but energy differences referring to all the configurations yield novel propositions about their part...

Treatment of boryllithium (THF)2Li[B(NDippCH)2] (Dipp = 2,6-diisopropylphenyl) with various amounts of AlMe3 or GaMe3 leads to the formation of inter group 13 compounds. Equimolar reactions result in ate complexes of the type (THF)nLi(Me3M)[B(NDippCH)2] (M = Al, Ga) with discrete (n = 2, 3) or eight-membered ring structures (n = 1). We reported previously that use of excessive amounts of group ...

The structure of molten LaBr3 was investigated by X-ray diffraction and molecular dynamics simulations. It was found that the short range structure of molten LaBr3 is very similar to that of molten LaCl3, except for some structural features such as interionic distances based on the difference of anion sizes. In the MD simulation, the shear viscosity of molten LaBr3 was estimated from the struct...