<p class="abstract">Langerhans cell histiocytosis is a condition of exceptional onset characterized by proliferative event dendritic cells with mono or multisystem involvement that predominates in the pediatric population and identified smaller proportion adults. It has clinical impact variable prognosis according to its location number organs affected. A 68-year-old male patient immunohi...

A 22-year-old man was referred to our institution due to lower back pain and was diagnosed with Langerhans cell histiocytosis of the thoracic and lumbar spine. The patient achieved complete remission with radiotherapy and chemotherapy. One year later, right cervical lymphadenopathy was observed and Hodgkin's lymphoma was confirmed on biopsy. The patient was treated with chemotherapy and autolog...

Histiocytosis X, or Langerhans cell histiocytosis (LCH), is a rare disease, with an estimated incidence of 1/200,000 per year in children under 15 years of age. It has a wide clinical spectrum, from single bone involvement (eosinophilic granuloma) to multisystemic disease with organ failure. The treatment of LCH is still controversial. While single system disease may spontaneously recover or re...

Pulmonary Langerhans' cell histiocytosis (PLCH) remains an important diagnostic consideration in the differential diagnosis of diffuse infiltrative lung disease, particular among smokers. This review highlights recent progress in our understanding of the etiology, clinical presentation, and diagnostic and therapeutic approaches to this unusual lung disorder. Evolving studies strongly link the b...

Pulmonary Langerhans cell Histiocytosis is a rare granulomatous disease affecting both sexes, with greater incidence in the second and third decades of life; smoking appears to be the most important risk factor. Its etiology is unknown, although there are data indicating an uncontrolled immune response as possible cause, sustained by the Langerhans cells, antigen presenting cells for T lymphocy...

A 5 year old boy presented with papules and nodules on face, chest and upper extremities and seborrhea of scalp for 4 years. Some old healed scars were also present. Lesions were pruritic to begin with but were non-itchy. Examination revealed erythematous plaques and nodules on face and upper limbs. Lesions were more marked on forehead, cheek (Fig. 1) and dorsum of hands. There were contracture...