The jejunum and ileum of 5 day old and adult normal pigs and of 45 day old germ free pigs were used to study the lymphocyte pools in the epithelium and lamina propria by sequential treatments with EDTA, four hours, and 12 hours of collagenase treatment. In adult animals the incubation of the jejunal wall with EDTA resulted in mean (SD) 26.8 (10.9) x 10(6) intraepithelial lymphocytes per g of ti...

BACKGROUND The costimulatory molecule OX40 and its ligand, OX40L, mediate key aspects of allergic airway inflammation in animal models of asthma, including eosinophilic airway inflammation, airway hyperresponsiveness, and T helper 2 polarization. We sought to examine OX40/OX40L and interleukin (IL)-4 expression in asthma across severities. METHODS Bronchial biopsies were obtained from 27 subj...

BACKGROUND Colorectal perineuriomas are uncommon benign mucosal-based proliferations of mesenchymal cells that express perineurial markers, often associated with colonic crypts displaying a serrated/hyperplastic architecture. The vast majority of cases arise distal to the splenic flexure and have been described as sessile polyps. Using molecular analysis, BRAF mutations have been demonstrated i...

Immunohistological analysis of the cellular composition of the small intestinal mucosa in a group of untreated and treated coeliac patients and non-coeliac control subjects was performed using monoclonal antibodies and an immunoperoxidase technique. A characteristic cellular distribution was observed within the normal mucosa. The intraepithelial and lamina propria compartments were occupied mai...

Recently, we published the first validated index to assess histological disease activity in UC. We believe that some clarifications have to be made regarding the assessment of this index in both clinical practice and clinical trials. Three histological criteria have to be assessed. The first criterion is the presence of mucosal ulceration defined by the loss of colonic crypts replaced with ‘imm...

OBJECTIVES To develop a canine model of vocal fold scar and to evaluate its treatment with lamina propria replacement therapy using autologous cultured fibroblasts. MATERIALS AND METHODS Full thickness of the lamina propria layer in canine vocal folds was injured with a laser. Fibroblasts were cultured and expanded in the laboratory from a buccal mucosal biopsy. The scarred vocal folds were t...

Page 2, lines 11 and 12: Does not make sense. The line begins with a number, and suggests that decreased number of lymphocytes are noted when the normal does not contain any.Modified & highlighted Page 2, lines 14 and 15: It would be d ifficult to understand what is outer third of lamina propria a better morphologic definition would be more appropriate. The point about Plasma cell is deleted al...

Human immunodeficiency virus (HIV) is transmitted primarily sexually across mucosal surfaces. After infection, HIV propagates initially in the lamina propria below the polarized epithelium and causes extensive destruction of mucosal T cells. Immunoglobulin A (IgA) antibodies, produced in the lamina propria and then transcytosed across the mucosal epithelium into the lumen, can be the first line...