نتایج جستجو برای: lactoferrin

تعداد نتایج: 3386  

Journal: :Blood 1992
J J Johnston P Rintels J Chung J Sather E J Benz N Berliner

Lactoferrin is a member of the transferrin family of iron-binding proteins. It is found in several glandular epithelial tissues and human neutrophils, where it is localized to secondary granules. To examine the mechanisms controlling lactoferrin gene expression in neutrophils and defects in its expression in acute leukemia, we have cloned a lactoferrin cDNA from a chronic myelogenous leukemia l...

Journal: :Investigative ophthalmology & visual science 1987
M Ballow P C Donshik P Rapacz L Samartino

Lactoferrin, an iron complexing protein in normal tears, is an important component of the nonspecific host defense system of the external eye. We measured tear lactoferrin levels in patients with contact lens-induced giant papillary conjunctivitis (GPC) by an enzyme-linked immunosorbent assay (ELISA). Patients with active GPC (N = 26) had significantly reduced tear levels of lactoferrin (0.876 ...

Journal: :The American journal of physiology 1998
Andrew J Ghio Jacqueline D Carter James M Samet William Reed Jacqueline Quay Lisa A Dailey Judy H Richards Robert B Devlin

Increased availability of catalytically active metal has been associated with an oxidative injury. The sequestration of transition metals within intracellular ferritin confers an antioxidant function to this protein. Such storage by ferritin requires that the metal be transported across a cell membrane. We tested the hypothesis that, in response to in vitro exposures to catalytically active met...

2014
Yi-Chieh Li Chang-Chi Hsieh

Hepatic manifestations of the metabolic syndrome are related obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease. Here we investigated how the anti-inflammatory properties of lactoferrin can protect against the onset of hepatic manifestations of the metabolic syndrome by using a murine model administered with high-fructose corn syrup. Our results show that a high-f...

2017
Kenya E. Fernandes Dee A. Carter

Lactoferrin is a multifunctional iron-binding glycoprotein belonging to the transferrin family. It is found abundantly in milk and is present as a major protein in human exocrine secretions where it plays a role in the innate immune response. Various antifungal functions of lactoferrin have been reported including a wide spectrum of activity across yeasts and molds and synergy with other antifu...

Journal: :Infection and immunity 1972
M S Leffell J K Spitznagel

Lactoferrin is contained in cytoplasmic granules of human polymorphonuclear leukocytes. Upon centrifugation, it sediments in a band of granules that also contain 50% of the lysozyme activity. This granule class is distinct from others associated with alkaline phosphatase and peroxidase. The granules are latent for lactoferrin as only lysed granules have the capacity specifically to inhibit anti...

Journal: :Folia histochemica et cytobiologica 2012
Napoleon Waszkiewicz Beata Zalewska-Szajda Anna Zalewska Magdalena Waszkiewicz Sławomir Dariusz Szajda Bernadeta Repka Agata Szulc Alina Kępka Alina Minarowska Sylwia Chojnowska Beata Konarzewska Jerzy Robert Ładny Urszula Kowzan Krzysztof Zwierz

Salivary lactoferrin is a glycoprotein involved in the elimination of pathogens and the prevention of massive overgrowth of microorganisms that affect oral and general health. A high concentration of lactoferrin in saliva is often considered to be a marker of damage to the salivary glands, gingivitis, or leakage through inflamed or damaged oral mucosa, infiltrated particularly by neutrophils. W...

2013
Margit Keresztes Tamás Horváth Imre Ocsovszki Imre Földesi Gyöngyi Serfőző Krisztina Boda Imre Ungi

BACKGROUND Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary...

Journal: :Clinical chemistry 2008
José Maria Moreno-Navarrete Francisco José Ortega Judit Bassols Antoni Castro Wifredo Ricart José Manuel Fernández-Real

BACKGROUND Lactoferrin, an innate immune protein with antiinflammatory properties, shows considerable antiatherosclerosis activity in animal studies. We investigated the relationship between circulating lactoferrin, lactoferrin gene (LTF, lactotransferrin) polymorphisms, dyslipidemia, and vascular reactivity in the context of glucose-tolerance status in men. METHODS We evaluated 2 nonsynonymo...

ژورنال: پیاورد سلامت 2009
اسلامی, محمد باقر, حسن پور, غلامرضا, صالحی نوده, علیرضا, فضلی, مرتضی, نصیری نژاد, سارا, نوروزی, مهدی,

Background and Aim : Lactoferrin is one of the milk components with the main role in iron absorption and transfer. As a result of this action the pathogens that need iron for their life cannot grow, so the infection will be controled, indirectly. Moreover, because the lactoferrin production is stopped in the women with breast cancer, evaluation of this protein in milk may be the first step in d...

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