Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 17 patients between September 2004 and August 2005 at the Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. These multidrug-resistant isolates, which belonged to a single clone, remained susceptible to colistin and tigecycline only and produced the carbapenem-hydrolyzing oxacillinase OXA-58. This study h...

Chromosome-Encoded Class D -Lactamase OXA-23 in Proteus mirabilis R. Bonnet,* H. Marchandin, C. Chanal, D. Sirot, R. Labia, C. De Champs, E. Jumas-Bilak, and J. Sirot Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, Laboratoire de Bactériologie, Hôpital Arnaud de Villeneuve, 34295 Montpellier Cedex 5, UMR 175, CNRS-MNHN, 29000 Quimper, Laboratoire de Bactériologi...

Carbapenem resistance has been encountered globally with poor outcome of infected patients. NDM-1 (New Delhi metallo-beta-lactamase) gene containing organisms have emerged and are now spreading in all continents. This is the first report of Iraqi patients referred to Lebanon from whom carbapenem resistant Enterobacteriaceae were recovered. The genes involved in carbapenem resistance were bla-OX...

Hospital-acquired infections with Acinetobacter spp. have been reported worldwide (13). Success of the organism is attributed to its ability for long-term survival in a hospital environment and its ability to rapidly acquire resistance to antimicrobials (2). Carbapenems have been the agents of choice for serious Acinetobacter sp. infections, but unfortunately the clinical utility of this class ...

The most frequent extended-spectrum -lactamases (ESBLs) in members of the family Enterobacteriaceae are derived from the clavulanic acid-inhibited Ambler class A enzymes TEM-1/ TEM-2 and SHV-1, which may hydrolyze ceftazidime and cefepime (4, 5). The Ambler class B enzymes have the broadest hydrolysis profiles, including cefepime and ceftazidime (8), whereas several OXA-derived ESBLs (Ambler cl...