Key words (–)-peyssonnoside A - diterpene glycoside marine natural product antimicrobial dearomative cyclization HAT-initiated Wittig reaction Mukaiyama hydration

The antimicrobial activity of fifteen semisynthetic labdane-type diterpenes derived from the two major natural compounds 3 and 4 of the resin "ladano" of Cistus creticus is reported. The chloroethyl carbamidic esters 15 and 20 showed the strongest antimicrobial activity against Gram(+), Gram(-) bacteria and pathogenic fungi.

Labda-8 (17), 12-diene-15, 16-dial and coronarin E were isolated from the chloroform extract of the rhizomes of Alpinia javanica. The structures were elucidated spectroscopically. This is the first report of the isolation of coronarin E from Alpinia species. The distribution of these two labdane diterpenes within the Zingiberaceae is reported.

MAGEE. T. V., and D. F. ZINKEL. 1986. A rapid method for diterpene resin acid analysis of pine needle oleoresin. Can. J. For. Res. 16: 1107-1109. A method for diterpene resin acid analysis has been developed for pine oleoresin samples at the submilligram level. The method utilizes the removal of acidic components by a micro-DEAE-Sephadex ion-exchange column and analysis of the recovered resin a...

Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE...

The product obtained in vitro from a diterpene synthase encoded in the genome of the bacterium Chitinophaga pinensis, an enzyme previously reported to have germacrene A synthase activity during heterologous expression in Escherichia coli, was identified by extensive NMR-spectroscopic methods as 18-hydroxydolabella-3,7-diene. The absolute configuration of this diterpene alcohol and the stereoche...

Following our interest in new diterpene glycosides with better taste profiles than that of Rebaudioside M, we have recently isolated and characterized Rebaudioside IX-a novel steviol glycoside-from a commercially-supplied extract of Stevia rebaudiana Bertoni. This molecule contains a hexasaccharide group attached at C-13 of the central diterpene core, and contains three additional glucose units...