p-Fluorophenylalanine (FPA) derepresses beta-galactosidase synthesis at 35 C but not at 25 C in Escherichia coli K-12, strain MC132 (lac I1,2), a strain with a temperature-sensitive lac repressor. In contrast, strain MC130 (lac I(+)) is not derepressed by FPA at 35 C. Temperature-shift experiments with strain MC132 in the presence of FPA and other reagents (isopropyl-1-thio-beta-d-galactoside o...

Distal half-kernels of barley (Hordeum vulgare L.), after imbibition for 1 day, produced a carboxypeptidase that was active on N-carbobenzoxy-l-phenylalanyl-l-alanine and on N-carbobenzoxy-l-phenylalanyl-l-phenylalanine. For the ensuing 2 days, activity increased linearly and thereafter increased at reduced rates. Electrofocusing of an imbibed half-kernel homogenate produced coincident peaks of...

The stimulation of ethylene production from seedling tissue of Phascolus vulgaris, Helianthus annuus and Zea mays by growth regulators was inhibited by actinomycin D and puromycin and to a lesser extent by 2-thiouracil and p-fluorophenylalanine. It is concluded that the mechanism of action of growth regulators on the enhancement of ethylene production is the formation of enzymes involved in eth...

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Two amino acid analogs, DL-p-fluorophenylalanine and L-3-nitrotyrosine, retarded the growth of Taper liver tumor in mice and increased mouse survival time. Both of the analogs were taken into the tumor cells in vitro and in vivo, and DL-p-fluorophenylalanine inhibited the uptake of L-phenylalanine in vitro. tRNA in the "pH 5 fraction" from tumor cells could be acylated with DL-p-fluorophenylala...