results the results obtained for each drug were compared with other drugs and also with the results of the control groups. the results related to promastigote and amastigote assays showed that when the dose of both drugs increased, the parasite number is reduced in comparison with the control groups. moreover, the parasitic burden in the test cultures decreased significantly. macrophage assay r...

Objective(s): To design a multivalent DNA vaccine encoding the most immunogenic regions of the Leishmania major antigens including TSA (Thiol-specific antioxidant protein), LmSTI1 (Leishmania major stress-inducible protein1), LACK (Leishmania homologue of receptors for activated C Kinase), and KMP11 (kinetoplastid membrane protein-11) on BALB/c mice.M...

Leishmania tropica and L. major are etiologic agents of human cutaneous leishmaniasis. Delayed type hypersensitivity (DTH) is an immunologic response that has been frequently used as a correlate for protection against or sensitization to leishmania antigen. In BALB/c mice, L. tropica infection results in non-ulcerating disease, whereas L. major infection results in destructive lesions. In order...

background: the seeds of some medicinal plants and their compounds have long been valued for their numerous health benefits. objective:to investigate some physical and chemical properties of salvia spp. methods: some physico-chemical properties in five species of salvia seeds (consisted of s. officinalis l., s. macrosiphon l., s. hypoleuca l., s. sclarea l. and s. nemorosa l.) were measured at ...

background: leishmaniasis is a common parasitic disease world wide. leishmania tropica and l. major are two common cause of cutaneous leishmaniasis in iran. the aim of this study was determination of the cause of cutaneous leishmaniasis in shush city, khouzestan province, southwest iran methods: one hundred samples were collected from patients at the age of 1-80 year with documented cutaneous l...

Background: Zoonotic cutaneous leishmaniasis (ZCL) is a polymorphic disease which may show various clinical manifestations. Although genetic variability of the parasite is suggested to be one of the factors influencing clinical manifestations in leishmaniasis, no data exist regarding genetic polymorphism of Leishmania major. Therefore, determination of genetic variation within the species of L....

ABSTRACT        Background and Objective: Leishmania major is a flagellate protozoan parasite causing cutaneous leishmaniasis. Although pentavalent antimony compounds are the first-line drugs for leishmaniasis, their application is often accompanied by numerous limitations and side effects. Therefore, it is necessary to seek drugs of herbal origin that have fa...