Rat brain SAM levels were markedly increased after methionine administration, whereas the convulsant, L-methionine-dl-sulphoximine (MSO), produced a 35 per cent decrease in whole brain content of S-adenosyl-L-methionine (SAM). When methionine was given in combination with MSO, SAM levels were not decreased. Studies on the regional distribution of SAM revealed only a small variation between regi...

Background: Literature data on the effect of methionine functional activity and, especially, morphological changes in liver parenchyma animals different ages are sporadic, and research results often ambiguous.
 Aim: The purpose this work was to study compare morphofunctional rats prolonged administration L-methionine.
 Material Methods: experiment performed 48 male Wistar 3 15 months ...

BACKGROUND Bacterial production of anionic sulphide is increased in the colon of ulcerative colitis and sulphides can cause metabolic damage to colonocytes. AIMS To assess the reversal of the damaging effect of sulphide to isolated colonocytes by methionine and methionine derivatives. METHODS AND SUBJECTS Isolated colonocytes were prepared from rat colons and 12 human colectomy specimens. I...

CONTEXT Increased levels of homocysteine are associated with risk of cardiovascular disease. Homocysteine may cause this risk by impairing endothelial cell function. OBJECTIVE To evaluate the effect of acute hyperhomocysteinemia with and without antioxidant vitamin pretreatment on cardiovascular risk factors and endothelial functions. DESIGN AND SETTING Observer-blinded, randomized crossove...

L-Homoserine was tritylated via its silylated product with Me2SiCl2 or Ph2SiCl2 in 65-68% yield. Also N-Trt-L-methionine upon treatment with Mel and degradation of the resulting sulfonium salt with KOH yielded N-Trt-L-homoserine in 75% yield. Both routes provided N-Trityl-L-homoserine with identical physical data. In contrast to N-alkyloxycarbonyl-L-homoserine derivatives, N-Trt-L-homoserine sh...

Based on the high radioactivity uptake of some 14C-labeled D-amino acids in tumors and pancreas of mice, this investigation was undertaken to ascertain possible usefulness of radioactive D-methionine as a nuclear imaging agent. Radioactivity derived from D-[3,4-14C]-methionine in Ehrlich solid tumor was approximately three times higher than that from the L-isomer, but was the same as for mouse ...

BACKGROUND AND PURPOSE Hyperhomocysteinemia is a vascular risk factor that infers with the nitric oxide signaling pathway of endothelial vasoregulation. Most investigations in young healthy humans on the peripheral vasculature using a standardized methionine challenge demonstrated altered vascular reactivity. In contrast, the cerebral autoregulation mechanism was shown to be unaffected by the s...