Prior work presented by us identified, in both pre-clinical models and a phase 2 clinical trial of sapanisertib (NCT02417701), that lung squamous cell carcinomas (LUSC) harboring NRF2 activating mutations are sensitive to treatment with the TORC1/2 inhibitor sapanisertib. Further preclinical data suggests suppression glycolysis is potentiated targeting glutaminolysis helps fuel Krebs cycle, whi...

The “citric acid cycle” hypothesis of carbohydrate oxidation has stimulated an interest in the general relationship of citric acid to carbohydrate metabolism. Krebs and Johnson (1937, a) and Krebs (1937) have presented evidence which they believe demonstrates that a catalytic system composed of certain dicarboxylic acids and citric acid “outlines the principal pathway of the oxidative breakdown...

A definite contribution of the glucuronic acid pathway to total glucose metabolism by rat adipose tissue in vitro in the presence of growth hormone preparations has not been found. Randomization of 14C of glucose-5-14C into glycerol and glucose-l-14C and -2-14C into glycogen on incubation of rat epididymal tissue indicates that the pathway contributes at most only a few per cent to the over-all...