A systematic appraisal of a large number of solvent systems was carried out for the separation of lactic, pyruvic and 3-hydroxybutyric acids and all of the KREBS cycle acids, except oxalosuccinic, using silica gel G and cellulose thin layer Chromatographie plates. Four solvent systems which allowed separation of various combinations of acids are described and the limits of this method of separa...

For many years it has been apparent from estimates of the anion gap and the strong ion gap that anions of unknown identity can be generated in sepsis and shock states. Evidence is emerging that at least some of these are intermediates of the citric acid cycle. The exact source of this disturbance remains unclear, because a great many metabolic blocks and bottlenecks can disturb the anaplerotic ...

To each connected component in the space of semisimple representations from the orbifold fundamental group of the base orbifold of a Seifert fibered homology 3-sphere into the Lie group U(2, 1), we associate a real number called the “orbifold Toledo invariant.” Using the theory of Higgs bundles, we explicitly compute all values this invariant takes on.

537 PERSPECTIVES E dwin G. Krebs, a giant of biomedical science in the 20th century, died on 21 December from congestive heart failure in Seattle at the age of 91. His discovery (with Edmond H. Fischer) of protein phosphorylation as a regulatory mechanism touched all aspects of biomedical science and profoundly infl uenced therapeutic approaches now used in clinical care. Ed's life epitomizes c...

The effects of liquid fluorocarbons as bathing media were determined by use of in vitro neuromuscular preparations. Rat hemidiaphragms were bathed in either oxygenated fluorocarbon (FC) emulsion or standard oxygenated Krebs solution. Contractile force in response to simple supramaximal nerve stimuli as well as to high frequency stimulation was greater, while twitch:tetanus ratio was smaller in ...

Armut ist ein Risikofaktor für Krebs. Menschen aus sozioökonomisch benachteiligten Gesellschaftsschichten erkranken häufiger und früher an Krebs, haben nach Diagnosestellung oftmals eine kürzere Lebenserwartung profitieren hinsichtlich des Gesamtüberlebens weniger von der Therapie. Diese Beobachtung hat sich im Zuge COVID-19-Pandemie weiter verschärft. Im vorliegenden Beitrag stellen wir zusamm...