The Gene Ontology (GO) is a comprehensive resource of computable knowledge regarding the functions of genes and gene products. As such, it is extensively used by the biomedical research community for the analysis of -omics and related data. Our continued focus is on improving the quality and utility of the GO resources, and we welcome and encourage input from researchers in all areas of biology...

A knowledge-based system consists of two main components, the knowledgebase and the inference mechanism. The former contains the problem solving knowledge, and the later provides the reasoning mechanisms to control this knowledge in finding a solution. Control mechanisms generally depend on the 'structure' and 'type' of design knowledge represented in the knowledgebase. This paper focuses on th...

TACITUS is a text understanding system being developed at SRI In­ ternational. One of the main components in the system is a knowledge­ base which contains commonsense and domain specific world knowledge encoded as axioms in a first order predicate calculus language. The prime function o f the knowledgebase is to provide extra-linguistic facts to be used in the resolution of a range of ambiguit...

The authors have previously described an approach for medical diagnostic reasoning based on the ST (Select and Test) model introduced by Ramoni and Stefanelli et al. This paper extends the previous approach by introducing the required algorithm for medical expert system development. The algorithm involves a bottom-up and recursive process using logical inferences, abduction, deduction, and indu...

Objective To develop and evaluate a pharmacogenomics information resource for pharmacists. Materials and Methods We built a pharmacogenomics information resource presenting Food and Drug Administration (FDA) drug product labelling information, refined it based on feedback from pharmacists, and conducted a comparative usability evaluation, measuring task completion time, task correctness and p...

Abstract—Healthcare safety has been perceived important. It is essential to prevent troubles in healthcare processes for healthcare safety. Trouble prevention is based on trouble prediction using accumulated knowledge on processes, troubles, and countermeasures. However, information on troubles has not been accumulated in hospitals in the appropriate structure, and it has not been utilized effe...

The mission of the Universal Protein Resource (UniProt) (http://www.uniprot.org) is to support biological research by providing a freely accessible, stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase. It integrates, interprets and standardizes data from numerous resources to achieve the most comprehensive catalogue of protein sequences and fu...

image completion is one of the subjects in image and video processing which deals with restoration of and filling in damaged regions of images using correct regions. exemplar-based image completion methods give more pleasant results than pixel-based approaches. in this paper, a new algorithm is proposed to find the most suitable patch in order to fill in the damaged parts. this patch selection ...