نتایج جستجو برای: kir gene

تعداد نتایج: 1142752  

Journal: :Blood 2007
Loredana Ruggeri Antonella Mancusi Marusca Capanni Elena Urbani Alessandra Carotti Teresa Aloisi Martin Stern Daniela Pende Katia Perruccio Emanuela Burchielli Fabiana Topini Erika Bianchi Franco Aversa Massimo F Martelli Andrea Velardi

We analyzed 112 patients with high-risk acute myeloid leukemia (61 in complete remission [CR]; 51 in relapse), who received human leukocyte-antigen (HLA)-haploidentical transplants from natural killer (NK) alloreactive (n = 51) or non-NK alloreactive donors (n = 61). NK alloreactive donors possessed HLA class I, killer-cell immunoglobulin-like receptor (KIR) ligand(s) which were missing in the ...

2003
P. Parham B. Dupont D. E. Geraghty J. Trowsdale D. Middleton C. Vilches M. Carrington C. Witt L. A. Guethlein H. Shilling C. A. Garcia K. C. Hsu H. Wain Steven G. E. Marsh Anthony Nolan

INTRODUCTION During discussion at the WHO Nomenclature Committee for Factors of the HLA System meeting in Victoria, Canada, in May 2002, it was decided to form a subcommittee to coordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors (KIRs) [1]. These genes are encoded on chromosome 19 (19q13.4) and have varying degrees of polymorphism. The receptors...

2016
Farhad Shahsavar Shaghayegh Mapar Seyyed Amir Yasin Ahmadi

Multiple sclerosis (MS) is a disease in which we can recognize destruction of the myelin that is around nerve cells of brain and spinal cord called as oligodendrocytes. Both genetic and environmental factors play roles in MS. One of these genes is the killer-cell immunoglobulin-like receptor (KIR) which expressed on surface of natural killer cells (NKs). These genes have loci (not locus) in hum...

2009
Ashley Moffett Susan Hiby

BACKGROUND Understanding of the immune events and mechanisms occurring at the feto-maternal interface is likely to help in understanding the ability of the fetus to survive within the maternal body. Evidence supporting extensive roles of natural killer cells during pregnancy gives rise to a possibility that these NK cells can be mis-regulated and involved in fetal allograft rejection. Killer im...

2012
Sumati Rajagopalan Eric O. Long

KIR2DL4 is an unusual killer cell immunoglobulin-like receptor (KIR) family member in terms of its structure, expression, cellular localization, and signaling properties. The most conserved KIR in evolution, it is referred to as a framework KIR gene and is expressed by all natural killer (NK) cells and a subset of T cells. Although it has a long cytoplasmic tail that is typical of inhibitory KI...

2016
Cristina Morales-Estevez Juan De la Haba-Rodriguez Barbara Manzanares-Martin Ignacio Porras-Quintela Antonio Rodriguez-Ariza Alberto Moreno-Vega Maria J. Ortiz-Morales Maria A. Gomez-España Maria T. Cano-Osuna Javier Lopez-Gonzalez Beatriz Chia-Delgado Rafael Gonzalez-Fernandez Enrique Aranda-Aguilar

Killer-cell immunoglobulin-like receptors (KIRs) regulate the killing function of natural killer cells, which play an important role in the antibody-dependent cell-mediated cytotoxicity response exerted by therapeutic monoclonal antibodies (mAbs). However, it is unknown whether the extensive genetic variability of KIR genes and/or their human leukocyte antigen (HLA) ligands might influence the ...

ژورنال: یافته 2011
انتظامی, کبری, شاهسوار, فرهاد, علی مقدم, کامران,

A potential factor influencing hematopoietic stem cells transplantation (HSCT) outcome is the presence of donor-derived alloreactive natural killer (NK) cells. This retrospective analysis studied the impact of NK alloreactivity based on the missing KIR ligand, for acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) patients undergoing non-T-cell depleted HLA-identical sibling HS...

2008
Derek Middleton Ashley Meenagh Juan Ignacio Serrano-Vela Juan Moscoso Antonio Arnaiz-Villena

HLA class I molecules are ligands for natural killer cells’ inhibitory (KIR DL) and activating (KIR DS) receptors. KIR DL receptors have a greater avidity for HLA class I molecules than KIR DS receptors. Thus, there is a possibility that HLA molecules drive KIR receptor selection. We have used the percentage of individuals bearing the genes KIR 3DS1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 2DL1, 2DL2, 2D...

Journal: :Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2013
Xiaoli Kang Jun Yu Yan Wei Peiquan Zhao

OBJECTIVES To investigate the situation of inwardly rectifying potassium channels Kir 2.1 and Kir 4.1 under hypo-xic conditions, and whether the A2A  receptor antagonist could modulate the mRNA expression of Kir 2.1 and Kir 4.1 channels in retinal Müller cells in vitro under hypoxic conditions. MATERIAL AND METHODS Müller cells were treated with 0.1 1, 10 and 100 µM of A2A  receptor antagonis...

Journal: :Immunology 2002
Zaheed Husain Chester A Alper Edmond J Yunis Devendra P Dubey

Human natural killer (NK) cells express several inhibitory and non-inhibitory NK receptors per cell. Understanding the expression patterns of these receptor genes in individual cells is important to understanding their function. Using a single-cell reverse transcription-polymerase chain reaction (RT-PCR) method, we analysed the expression of nine NK receptor genes in 38 resting CD56+ NK cells f...

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