The inhibitive performance of the methanol extract an eco-friendly green inhibitor Kalanchoe crenata (KC) leaves on corrosion mild steel in 5.0 M H2SO4 solution with concentrations 1 g/L, 2 3 4 g/L and 5 at temperatures 333 K 353 was studied using gravimetric (weight loss) gasometric (hydrogen evolution) techniques to determine its inhibition efficiencies as well depict mechanism inhibitor. tec...

Reproducibility of biological data is a significant problem in research today. One potential contributor to this, which has received little attention, is the over complication of enzyme kinetic inhibition models. The over complication of inhibitory models stems from the common use of the inhibitory term (1 + [I]/Ki ), an equilibrium binding term that does not distinguish between inhibitor bindi...

CYP2C9 substrates can exhibit both hyperbolic and atypical kinetic profiles, and their metabolism can be activated or inhibited depending on the effector studied. CYP2C9 genetic variants can also affect both substrate turnover and kinetic profile. The present study assessed whether analogs of the effector amiodarone differentially altered the atypical kinetic profile of the substrate naproxen a...

background: the purpose of this study was to investigate the ratio of electromyography (em g) activities of the vastus medialis obliqus (vmo) and vastus lateralis (vl) within seven angles of knee joint range of motion using isometric contraction in open kinetic chain (ok c) and closed kinetic chain (ckc). methods: the dominant knees of 44 healthy female subjects (mean age: 24.84 with range: 20-...

Amentoflavone has been identified as a JAK2 inhibitor by structure-based virtual screening of a natural product library. In silico optimization using the DOLPHIN model yielded analogues with enhanced potency against JAK2 activity and HCV activity in cellulo. Molecular modeling and kinetic experiments suggested that the analogues may function as Type II inhibitors of JAK2.

background : to determine the role of letrozole, an aromatase inhibitor,in the treatment of endometriotic pain.   methods: in this prospective, randomized, controlled clinical trial in minimallyinvasive surgery research center,51 women with pelvic endometriosis and endometriotic pain (dyspareunia, dysmenorrhea, pelvic pain) score of 5 or more (for at least one of these endometriotic pain), afte...

angioedema is an asymmetric non-pitting oedema on face, lips, tongue and mucous membranes; any delay in diagnosis and treatment can be fatal. treatment with lisinopril as an angiotensin converting enzyme (ace) inhibitor, can be a reason of angioedema. here we report a case who developed oral-facial edema four years after using lisinopril/hydrochlorothiazide. laryngeal oedema is a main cause of ...

background sivelestat is a neutrophil elastase inhibitor (nei) with positive impact on the respiratory complications in thoracic surgery. based on the findings of a recent study, nei may have a good response for avoiding ischemia reperfusion injury in liver resection. conclusions intravenous nei administration had positive impact on the postoperative inflammatory response and oxygenation while ...

Large numbers of native-fitting and random-coil conformations of a small protein, pancreatic trypsin inhibitor, have been generated as self-avoiding random walks on a face-centred cubic lattice. Randomcoil conformations similar to the native X-ray conformation occur frequently enough to suggest that well-defined kinetic pathways for protein folding are not as necessary as is usually thought.

The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated using benzylamine as amine component. The products obtained from this biotransformation in high enantiomeric purity can serve as valuable precursors for various amino alcohols, as exemplified by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine.