Interleukin-12 (IL-12) is a recently described iminunoregulatory cyto kine with potent therapeutic activity in various preclinical models of infectious or malignant disease. As part of our ongoing evaluation of potential mechanisms accounting for the potent antitumor activity of IL-12,wehaveinvestigatedtheinfluenceof IL-12administrationontotal serum nitrate/nitrite (NO@)levels and the productio...

Rationale: Remote ischemic conditioning induced by repeated episodes of transient limb ischemia is a clinically applicable method for protecting the heart against injury at the time of reperfusion. Objective: To assess the effect of chronic, repeated, remote conditioning on infarct size and long-term remodeling after myocardial infarction. D espite the timely application of reperfusion therapy,...

Many tumor-associated antigens are derived from nonmutated "self" proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo with vaccination. These T cells exist in a functionally tolerant state, as they rarely result in tumor eradication. We found that tumor growth and lethality were unchanged in mice even after adoptive transfer...

In 1998, Hu and Xing (1998) developed a method for nerve injury by chronically compressed dorsal root ganglia (CCD). Robert LaMotte and his colleagues at Yale have utilized this technique to explore the consequences of injury on nociception and excitability of primary sensory neurons. This elegant model closely resembles common compressive injuries that occur in people and allows investigations...

On behalf of the H1 and ZEUS Collaborations At HERA 27.5 GeV positrons collide with 820 GeV protons. The relevant kine-matical parameters are an ep center-of-mass energy p s = 300 GeV and a photon virtuality in the range 0 < Q 2 < 10 5 GeV 2. Given the intense ux of photons emitted by the positron beam, photon-proton collisions can be studied for p center-of-mass energies 20 < Wp < 300 GeV. In ...

Any gaseous material along our line of sight to distant quasars or, more generally, active galactic nuclei (AGNs) will absorb light according to the amounts and range of ions present. Strong absorption lines are common in rest-frame UV spectra of AGNs due to a variety of resonant transitions, for example the HI Lyman series lines (most notably Lyα λ1216) and high-ionization doublets like CIV λλ...

Setting a new standard for kinetochores T o really understand how a biological structure works, we need to know not just which, but also how many, molecules are present in it. For kine-tochores—the structures that link centro-meric DNA to spindle microtubules— protein components have been tallied by comparing the fluorescence of GFP-tagged kinetochore proteins to fl uorescent versions of the ce...

Velocity, chemical abundance and spatial distribution data for some 1500 K-and M-giants in the Galactic Bulge, which are presented in an accompanying paper (Ibata & Gilmore 1995), are analysed. We provide three levels of analysis: an almost model-independent determination of basic symmetry properties of the galactic bulge; a more detailed analysis based on conservative assumptions, which invest...

1971). The details of the in vivo search process have been examined only recently, but some insights into New York University School of Medicine 540 First Avenue antigen-specific T cell-APC interactions have been generated by in vitro studies. New York, New York 10021 In vitro antigen-specific T cell-APC interactions were observed as early as the 1970s when in vitro antigen-specific T cell syst...

Any gaseous material along our line of sight to distant quasars or, more generally, active galactic nuclei (AGNs) will absorb light according to the amounts and range of ions present. Strong absorption lines are common in rest-frame UV spectra of AGNs due to a variety of resonant transitions, for example the HI Lyman series lines (most notably Lyα λ1216) and high-ionization doublets like CIV λλ...