Vascular and lymphatic malformations represent a challenge for clinicians. The identification of inherited somatic mutations in important signaling pathways, including the PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target rapamycin), RAS (rat sarcoma)/RAF (rapidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated ki...

Liver fibrosis is an outcome of many chronic liver diseases and often results in cirrhosis, failure even hepatocarcinoma. Zhuyu zhenggan decoction as a classical traditional Chinese medicine formula used to clinical practice while its mechanism unclear. The aim this study was investigate the anti-fibrosis effect explore molecular mechanisms by combining network pharmacology animal experiment. c...

Piperine is a dietary alkaloid with huge pharmacological importance and was first isolated from pepper extract. It has been reported anti-cancer, anti-amoebic, anti-mycobacterial, anti-mutagenic, anticonvulsant, anti-asthmatic, immunomodulatory, anti-inflammatory anti-oxidant activity. Therefore, the current investigation designed to unveil anticancer effects of piperine molecule against human ...

Background: The cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. This study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. Methods: Five groups (7 each) of male Sprague-Dawley rats, including a control group, a diabetes (induced by Streptozocin and Nicotinamide)...

Significant inhibition of Aurora B was achieved by the synthesis simplified fragments benzosceptrins and oroidin belonging to marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation kinase enabled discovery a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into potent CJ2-150 (37). Here we present new inhibitors...

objective: signaling pathways such as extracellular regulated kinase/mitogen activated protein kinase (erk/mapk) have increased activity in leukemia. ribosomal 6 kinase (rsk4) is a factor downstream of the mapk/erk pathway and an important tumor suppressor which inhibits erk trafficking. decrease in rsk4 expression has been reported in some malignancies, which leads to an increase in growth and...

abstract accumulation of gene changes and chromosomal instability in response to cellular dna damage lead to cancer. dna damage induces cell cycle checkpoints pathways. checkpoints regulate dna replication and cell cycle progression, chromatin restructuring, and apoptosis. checkpoint kinase 2 (chk2) is activated in response to dna lesions. atm phosphorylate chk2. the activated chk2 kinase can p...

acute lymphoblastic leukemia(all) is due to early stage arrest of lymphoblast development. the translocation of philadelphia (ph) chromosome occurs as a result of the bcr-abl fusion gene, which constitutively produced activated tyrosine kinase. this gene fusion is an important indicator for prognosis in all and is associated with poor overall survival and remission duration. bcr-abl could inter...

The aim of the study was to evaluate usefulness determining markers myocardial damage, such as: aspartate aminotransferase, total creatine kinase, cardiac kinase isoenzyme, lactate dehydrogenase, dehydrogenase isoenzyme and peripheral blood lactic acid in sport horses subjected physical exertion. research carried out on 50 three breeds: Ukrainian Riding, Hanoverian Westphalian, aged 4-16 years....

Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the...