The aim of this study was to evaluate the genotoxic effects of a crude extract of khat (Catha edulis, Forsk) leaves in rats. Two groups were fed khat crude extract, 1000 and 2000mg/kg body weight, for 90 days and were compared with a control group. The alkaline (pH>13) version of comet assay was used in this study. However, no previous published work has been undertaken and showed the effect of...

Background: This study aimed to explore the barriers and enablers to quitting khat from the perspective ofusers and the barriers and enablers to supporting users to quit from the perspective of healthcareprofessionals (HCPs).Methods: The present qualitative study was conducted using semi-structured interview...

Khat, an "amphetamine-like green leaf," may influence the consumption of tobacco. This study reviews the epidemiology of tobacco use among khat users. Electronic database searches using appropriate keywords/terms were conducted to identify observational studies of khat use. Assessment of quality and risk of bias of all included studies was conducted, and the results were synthesised descriptive...

Khat is considered a psychoactive drug and has many side effects on different parts of the body organs. In this study the effects of khat on sperm count and motility in parent mice and their offspring were investigated. Animals were divided into two groups, Group 1 (khat group) contained twelve male and twelve female mice, and they were given a daily dose of (50mg/kg) body weight khat extract b...

During the past 20 years or so, more has become known about the properties of khat, its pharmacology, physiological and psychological effects on humans. However, at the same time its reputation of social and recreational use in traditional contexts has hindered the dissemination of knowledge about its detrimental effects in terms of mortality. This paper focuses on this particular deficit and a...

Background: Khat (Catha edulis forks, family: celastraceae) is a plant grown in East-Africa and the south west of the Arabian Peninsula. People uses for its pleasant stimulant effect of physical activity, consciousness, motor and mental functions as well as its anti-fatigue action. Although there is a rich body of research available regarding the effect of acute and chronic khat dosing in anima...

Fresh leaves of the khat tree (Catha edulis Forsk.) are chewed for their euphoric properties in East Africa and parts of the Middle East, such as The Yemen. This review describes the history, cultivation and constituents of khat, and the social aspects of khat chewing in Yemen. The major pharmacologically active constituent of the fresh leaves is (--)-S-cathinone. The pharmacology of (--)-S-cat...

Use of substances such as alcohol, khat leaves (Catha edulis) and tobacco has become one of the rising major public health and socioeconomic problems worldwide [1]. Recent trends indicate that the use of substances have dramatically increased particularly in developing countries [1]. Alcohol, especially in high doses, or when combined with khat or tobacco, continues to claim the lives of many p...

AIM OF THE STUDY This article looks at the history of the expansion of khat consumption from the traditional chew regions to Western countries and assesses the implication of possible international control for its use and trade in the Horn of Africa. MATERIALS AND METHODS Ten months of initial field work in Ethiopia, three follow up field work, archival work in Ethiopia and Europe, as well as...

BACKGROUND Khat (Catha Edulis Forsk) is a natural psychoactive substance that contains addictive substances such as Cathine and Cathinone which have similar structure and action to amphetamine. This substance has been suggested that it can decrease perceived exertion and thus improve performance. There is no study in the literature regarding the effect of khat on exercise performance. Therefore...