The crucial balance of stability in blood-circulation and tumor-specific delivery has been suggested as one the challenges for effective bench-to-bedside translation nanomedicines (NMs). Herein, we developed a supramolecularly enabled tumor-extracellular (Tex) pH-triggered NM that can maintain micellar structure with entrapped-drug during systemic circulation progressively release drug tumor by...

As the number of systems which offer annotations on digital documents increases, robust anchoring of annotations is a key challenge. It is especially important if the annotator lacks write-access to the document being annotated. For example, if someone makes an annotation on a web page today and the web page changes tomorrow, what happens to the annotation? One approach is simply to “orphan” th...

this work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. in-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared ...

Micelle gel is a radiochromic hydrogel with the potential to be used as a three dimensional (3D) radiation dosimeter. Since an ideal dosimeter should present water equivalent properties, in this study the water equivalence of two formulations of micelle gel has been investigated by calculating electron density, effective atomic number, fractional interaction probabilities, mass attenuation coef...

In this paper, the dynamic assembly of toroidal micelle structures of amphiphilic triblock copolymers in dilute solution has been investigated using dissipative particle dynamics simulations. The amphiphilic molecule is represented by a coarse-grained model, which contains hydrophilic and hydrophobic particles. Some microstructures of complex morphology having toroidal micelles have been observ...

A distinct tadpole-shaped nanostructure characterized by a spherical head and an extended shaft was identified in a single plasmid DNA (pDNA)-based polymeric micelle. The tadpole-shaped structure was constructed by adding anionic chondroitin sulfate (CS) to the rod-shaped polyplex micelle containing a single pDNA molecule packaged by the PEG-polycation block copolymer through their electrostati...

Methylene Blue, Reversed Micelles, Water Content, Solubilization The solubilization of methylene blue in dodecylammonium propionate reversed micelles in cyclohexane depended strongly on the solubilized water content. Methylene blue solubilized in the micelle of which head groups are not completely hydrated by bound water exhibited the new absorption bands at 495 and 270 nm, but these bands did ...