Introduction: Diabetic macular edema (DME) is a debilitating complication of the diabetic eye. Vascular Endothelial Growth Factor (VEGF) was found to be responsible for this disease entity, and anti-VEGF remains main treatment DME. Inflammatory processes occur in eye, with some researchers postulates role them making This study’s objective search alternative using Non-Steroid Anti-Inflammatory ...

In modern medicine, one of the most common situations requiring emergency care is biliary or renal colic as a manifestation abdominal pain syndrome. both cases, smooth muscle spasm plays an important role in pathogenesis visceral Taking into account fact that, regardless chosen treatment tactics, at first stage it necessary to stop pain, question arises about choice drug strategy for relief the...

A glassy carbon electrode modified with a coating of polypyrrole (Ppy) exhibited an attractive performance for the detection and determination of a non-steroidal and non-narcotic analgesic compound, ketorolac tromethamine (KT). Cyclic voltammetry, differential pulse and square wave voltammetry were used in a combined way to identify the electrochemical characteristics and to optimize the condit...

BACKGROUND AND OBJECTIVES: Understanding that pain is the most important postoperative problem, in face to the need of establishing a therapeutic protocol to control post-tooth extraction pain and due to few studies comparing these drugs is that our study is justified. This study aimed at evaluating and at comparing the preemptive analgesic effect of two drugs, both administered in bolus. METHO...

A simple, RP-HPLC method was established for determining moxifloxacin and ketorolac in pharmaceutical formulations. Moxifloxacin, ketorolac and their degradation products were separated using C8 column with methanol and phosphate buffer pH 3.0 (55:45 v/v) as the mobile phase. Detection was performed at 243 nm using a diode array detector. The method was validated using ICH guidelines and was li...

BACKGROUND The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an orifice drilled on it by means of a laser beam or mechanical drill. Ketorolac is a nonsteroidal agent with powerful analgesic. Oral bioavailability of ketorolac was reported to be 90% with very low hepatic first-pass...