The question of whether appreciable amounts of ethanol can become absorbed into the bloodstream through intact skin arises from time to time in connection with drunk-driving litigation (1). However, to produce an elevated blood-ethanol concentration (BEC), the amounts of alcohol taken up through the skin must exceed the amounts eliminated by metabolism in the liver and excretion in the breath a...

Previous studies have shown that caffeine has beneficial effects on cognitive impairment in sleep deprived male rats. Therefore in the present study, we examined the effects of chronic caffeine administration on learning and memory impairments induced by sleep deprivation (SD) in the intact and ovarectomized (OVX) female rats. Two sets of animals including intact and OVX were randomly recruited...

Trbolová, A. , I . Kozák, L. Kolodzieyski , T. Juhás, V. Ledeck ̆: Keratoplasty á Chaud, Limbal Autotransplantation and Transplantation of Amniotic Membrane in the Management of Severe Chemical Burns of the Eye. Acta Vet. Brno 2003, 72: 571-576. The purpose of this study was to assess the efficacy and safety of the management of severe chemical eye injuries using early keratoplasty combined with...

The purpose of this study was to quantitatively assess the pupillary light reflex (PLR) in normal and anesthetized dogs using a pupillometer. Eleven dogs (20 eyes) of various breeds were included. PLRs were measured with a handheld pupillometer in dim light before and during anesthesia. Anesthesia was conducted with atropine, xylazine and ketamine. Parameters of pupillometry included neurologic...

At the time of surgery, occult metastases (micrometastases) are present in more than 50% of colorectal cancer patients, and the liver is the most frequent site of apparent metastatic disease. Frequently, adjuvant chemotherapy is unable to prevent tumor recurrence. Thus, novel therapeutic strategies are warranted. The aim of this study was to establish a model of human colon cancer metastatic to...

At the time of surgery, occult metastases (micrometastases) are present in more than 50% of colorectal cancer patients, and the liver is the most frequent site of apparent metastatic disease. Frequently, adjuvant chemotherapy is unable to prevent tumor recurrence. Thus, novel therapeutic strategies are warranted. The aim of this study was to establish a model of human colon cancer metastatic to...