Background: The aim of this study was to perform a systematic review and meta-analysis on available data about glucose-6-phosphate dehydrogenase enzyme deficiency (G6PDD) status in Iranian neonates screened for the disease. Methods: A literature search was conducted in electronic databases of Embase, PubMed, Web of Sciences, Scopus and Google Scholar for articles published from inception to 1 ...

Neonatal jaundice is a common disorder worldwide affecting 30-70% of newborn infants. Severe neonatal and its progression to kernicterus leading cause death disability among newborns in poorly-resourced countries. OBJECTIVES: To determine the frequency congenital hypothyroidism new born admitted with at tertiary care hospital Peshawar. METHODOLOGY: Settings: removed for blind review Duration: P...

Children constitute a vulnerable group since a new drug gets released to the market without the benefit of even limited experience in them. Adequate controlled clinical trials in children, with the notable exceptions of pediatric oncology and vaccinations, are lacking because of ethical considerations. Only a vigilant postmarketing surveillance detects ADRs occurring uniquely in children, for e...

Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased ...

Abstract Background The risk of kernicterus and BIND may be in part determined by total serum bilirubin (TSB) the level non-albumin bound free bilirubin, which can easily pass blood–brain barrier. Free (Bf) seems a more reliable predictor for neurotoxicity. Bilirubin/albumin ratio (B/A) is considered surrogate parameter Bf has been useful than TSB. aim study to determine whether B/A correlates ...