PURPOSE The purpose of this study is to describe the ineffectiveness of intrastromal voriconazole injection for filamentous fungal keratitis by contrasting the effectiveness for yeast keratitis. METHODS We examined seven fungal keratitis patients prospectively. All yeast was identified by molecular phylogenetic analyses of the chromosomal regions coding for the D1/D2 domain of the large-subun...

BACKGROUND Mycotic keratitis is an important cause of corneal blindness world over including India. Geographical location and climate are known to influence the profile of fungal diseases. While there are several reports on mycotic keratitis from southern India, comprehensive clinico-microbiological reports from eastern India are few. The reported prevalence of mycotic keratitis are 36.7%,36.3%...

THE concept of an association between congenital syphilitic interstitial keratitis and the development of late glaucoma is not new. Hutchinson (1863) reported the case of a man aged 24 with congenital syphilis who had suffered bilateral interstitial keratitis at the age of 6; both eyes had deeply cupped and atrophic optic discs and iridectomy failed to control the glaucoma. Hutchinson believed ...

Scanning electron microscopy of the endothelium of experimental disciform keratitis revealed corneal endothelial changes which distinguished disciform oedema from the more progressive stages of disciform keratitis. The endothelium of corneas with disciform oedema were wholly intact and characterised by subtle morphological alterations. In contrast, the more progressive stages of disciform kerat...

Photodynamic inactivation of virus was tested as a potential therapeutic tool for herpesvirus-induced keratitis, which is a leading cause of blindness and disability. Experimental keratitis produced in rabbits by infection with herpesvirus isolated from a human periorbital lesion was treated with proflavine and light. The herpetic keratitis could be rapidly resolved by the dye-light treatment, ...

We aim to highlight the key factors for a good outcome of fungal keratitis. We describe a case of contact lens-related Fusarium keratitis in a young girl. After identification of Fusarium spp under direct microscopic examination and in culture, a prolonged treatment with topic natamycin 5% was started and administered for five months with restitutio ad integrum of the eye. Prompt microbiologica...

Eikenella corrodens is a Gram-negative facultative anaerobe which is part of the normal human oropharyngeal flora and an opportunistic pathogen of mucous membrane tissues. We report a case of secondary E. corrodens ulcerative keratitis with hypopyon in a 39-year-old male with herpes simplex keratitis. To the best of our knowledge this is the first reported case of E. corrodens as a pathogen in ...

Background: Fungal keratitis is an acute or chronic inflammation of the cornea caused by fungi. The main treatment for fungal Natamycin 5%. Disadvantages natamycin are its poor penetration and increased resistance due to fungi which lower level ergosterol in wall. Purpose: Investigates effect bromelain, zingibain papain on LOX-1 receptors Aspergillus fumigatus. Result: receptor with bromelain p...

purpose : identifying the predisposing factors of the infectious keratitis results in understanding the underlying mechanisms of its expansion and severity that is essential for initiation of optimal empirical antimicrobial therapy. this study identified main predisposing factors of bacterial keratitis in a sample of iranian population. methods : ninety patients with bacterial keratitis were pr...