BACKGROUND Chemokines are involved in the pathogenesis of osteoarthritis (OA). CCL18, a member of the chemokines family, is observed in synovial fluid (SF) of OA patients. The aim of this study was to determine the association between CCL18 levels in serum and SF with radiographic knee OA. MATERIAL AND METHODS This study was conducted in a population of 308 patients with knee OA. The radiolog...

The founders of the Arthritis Research Campaign (arc) Epidemiology Unit were Kellgren and Lawrence. Their initial work was conducted in miners and then in the general population. They pioneered standardized methods of interview, examination and X-ray evaluation. They also played a key role in the early development of classification criteria for use in epidemiological surveys. The second directo...

BACKGROUND Nesfatin-1, a member of the adipokine family, has been detected in synovial fluid (SF) from OA patients. This study aimed to determine whether there is a marked correlation of nesfatin-1 levels in serum and SF of knee OA patients with the disease severity of OA. MATERIAL AND METHODS This cross-sectional research enrolled 202 knee OA subjects. The Kellgren-Lawrence grading system wa...

Methods: As the Multicenter ACL (anterior cruciate ligament) Revision Study (MARS) Group, we conducted a multicenter, prospective longitudinal cohort study of patients undergoing revision surgery after anterior cruciate ligament reconstruction. We followed 632 patients who underwent radiographic evaluation of the knee (an anteroposterior weight-bearing radiograph, a posteroanterior weight-beari...

A case-control study was conducted to evaluate the association between knee osteoarthritis (OA) and physical activity (PA) among a community group aged 40 years and older. Case patients (85 males, 154 females) had radiologically confirmed knee OA with grade 2+ changes, according to Kellgren and Lawrence criteria. Control subjects (85 males, 154 females) had no radiologic evidence of knee OA. A ...

INTRODUCTION Post-traumatic osteoarthritis (PTOA) is the unfortunate outcome of many high-energy fractures of the tibial plafond. The severity of the fracture is a major risk determinant. The inability to objectively quantify fracture severity has confounded efforts to determine the efficacy of different treatments aimed at preventing the PTOA development. A CTbased measure of fracture energy w...

Our aim in this longitudinal study was to evaluate to what extent fat and lean tissue mass variations are associated and can predict RKOA in a large sample of British women followed-up over 10 years. Kellgren/Lawrence (K/L), joint space narrowing (JSN) and osteophyte (OSP) grades were scored from radiographs of both knees in 909 middle-aged women from the Chingford registry. Body composition co...

In this paper, we investigate the effect of squeeze-and-excitation blocks on improving classification quality osteoarthritis using convolutional neural networks ResNet and DenseNet families. We show that use these improves according to Kellgren-Lawrence scale by 1–3 % without a significant modifi-cation model structure. also demonstrate combining 0 1 classes into one class allows increase accur...

It has been suggested that arthrodesis of the ankle leads to osteoarthritis of the joints of the ipsilateral hind- and midfoot. We believe these studies overlooked the presence of osteoarthritic changes in these joints before the arthrodesis. We reviewed the pre-operative radiographs of 70 patients with osteoarthritis of the ankle who underwent 71 ankle arthrodeses (one was bilateral). The talo...

This study examined the contribution of the osteoarthritis (OA) susceptibility genes ASPN, GDF5, DIO2, and the 7q22 region to the development of radiographic knee OA in patients with a mean age of 40.6 ± 7.9 years (standard deviation) and who suffered from nonacute knee complaints a decade earlier. Dose-response associations of four single nucleotide polymorphisms(SNPs) in the susceptibility ge...