BACKGROUND Pituitary adenylate cyclase activating peptides (PACAPs) are potent endothelium independent dilators of human coronary arteries; however, their effects on human pulmonary arteries are unknown. METHODS The vasorelaxant effects of PACAP27 on human pulmonary segmental arteries were studied and the specific potassium (K+) channel regulatory mechanisms in the vasorelaxant effects were t...

This study examines the problem of fragmentation asynchronous online discourse by using Knowledge Connection Analyzer (KCA) framework and tools explores how students could use KCA data in classroom reflections to deepen their knowledge building (KB) inquiry. We applied nine Forum® (KF) databases examine framework, identify issues with that may inform further development, provide on work. Our co...

As they proliferate, living cells undergo transitions between specific molecularly and developmentally distinct states. Despite the functional centrality of these transitions in multicellular organisms, it has remained challenging to determine which transitions occur and at what rates without perturbations and cell engineering. Here, we introduce kin correlation analysis (KCA) and show that qua...

A minimal model is presented to explain changes in frequency, shape, and amplitude of Ca2+ oscillations in the neuroendocrine melanotrope cell of Xenopus Laevis. It describes the cell as a plasma membrane oscillator with influx of extracellular Ca2+ via voltage-gated Ca2+ channels in the plasma membrane. The Ca2+ oscillations in the Xenopus melanotrope show specific features that cannot be expl...

The mechanism of action of tonically applied choline, the agonist of α7 nicotinic acetylcholine receptors (nAChRs), to the spontaneous and evoked release of a neurotransmitter in mouse motor synapses in diaphragm neuromuscular preparations using intracellular microelectrode recordings of miniature endplate potentials (MEPPs) and evoked endplate potentials (EPPs) was studied. Exogenous choline w...

We tested the hypothesis that changes in arterial blood flow modify the function of endothelial Ca -activated K channels [calcium-activated K channel (KCa), small-conductance calciumactivated K channel (SK3), and intermediate calcium-activated K channel (IK1)] before arterial structural remodeling. In rats, mesenteric arteries were exposed to increased [ 90%, high flow (HF)] or reduced blood fl...

The extraction of high-quality keywords and sum-marising documents at a high level has become more difficult in current research due to technological advancements the expo-nential expansion textual data digital sources. Extracting summarising high-level need use features for keyphrase extraction, becoming popular. A new unsupervised concentrated area (KCA) identification approach is proposed th...

Similar to GABAA receptor-channels the calciummediated gating of the small-conductance KCa2 and the intermediate-conductance KCa3.1 channels can be positively or negatively modulated by small molecule drugs, which, in analogy to the GABA field, have been termed positive (PAM) or negative allosteric modulators. While positive gating modulators like EBIO, NS309, SKA-31 and SKA-121 shift the calci...