gastroduodenoscopy as part of a general checkup at a private clinic, and was referred to our hospital with a suspected submucosal tumor of the esophagus. The patient had no symptoms and was in good health except that he was taking aspirin for angina pectoris, although he had not experienced any cardiac events in the past 6 years. On physical examination, the abdomen was flat and soft. Laborator...

Mercaptopurine. L. Lee Bennett, Jr., and Paula W. Allan. 159 Nuclear Pockets Associated with the Nucleolus in Normal and Neoplastic Cells. E. Robert Burns, Bernard L. Soloff, Calvin Hanna, and Donald F. Buxton. 166 The Synergism between Radiation and Estrogen in the Production of Mammary Cancer in the Rat. Albert Segaloff and William S. Maxfield 169 The Effect of L-Asparaginase on Mitotic Activ...

The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly defined. Feeding mice a diet deficient in methionine and choline (MCD diet) induces experimental NASH. Osteopontin (OPN) is a Th1 cytokine that plays an important role in several fibroinflammatory diseases. We examined the role of OPN in the development of experimental NASH. A/J mice were fed MCD or control diet for up to 12 wk, ...

We cloned and sequenced the gene encoding an NADPH-dependent aldehyde reductase (ARII) in Sporobolomyces salmonicolor AKU4429, which reduces ethyl 4-chloro-3-oxobutanoate (4-COBE) to ethyl (S)-4-chloro-3-hydroxybutanoate. The ARII gene is 1,032 bp long, is interrupted by four introns, and encodes a 37,315-Da polypeptide. The deduced amino acid sequence exhibited significant levels of similarity...

Aureochrome-1 (AUREO1) is a blue light (BL) receptor that mediates the branching response in stramenopile alga, Vaucheria frigida. AUREO1 contains a basic leucine zipper (bZIP) domain in the central region and a light-oxygen-voltage sensing (LOV) domain at the C terminus, and has been suggested to function as a light-regulated transcription factor. We have previously reported that preparations ...

We reported previously [Kataoka, Muroi, Ohkuma, Waritani, Magae, Takatsuki, Kondo, Yamasaki and Nagai (1995) FEBS Lett. 359, 53-59] that prodigiosin 25-C (one of the red pigments of the prodigiosin group produced by micro-organisms like Streptomyces and Serratia) uncoupled vacuolar H+-ATPase, inhibited vacuolar acidification and affected glycoprotein processing. In the present study we show tha...