نتایج جستجو برای: kainic acid

تعداد نتایج: 747449  

Journal: :Journal of Drug Delivery and Therapeutics 2021

Considering the prevalence of epilepsy and problems associated with currently available antiepileptic drugs like side effects, resistance, safety issue high cost, herbal medicine fewer complications could be very appropriate alternative. Therefore in present study, we have examined properties ethanolic extract leaves mice using maximal electroshock seizers (MES)test, Pentylenetetrazole (PTZ), i...

2013
Mami Noda Kaoru Beppu

Abbreviations: AMPA: α-amino-hydroxy-5-methyl-isoxazole4-propionate; ATP: Adenosine Triphosphate; BDNF: Brain-Derived Neurotrophic Factor; CNS: Central Nervous System; EAAT: Excitatory Amino-Acid Transporter; FGF: Fibroblast Growth Factor; GDNF: Glial-Derived Neurotrophic Factor; GLAST: Glutamate Aspartate Transporter; GLT-1: Glutamate Transporter-1; NO: Nitric Oxide; IL3: Interleukin-3; IL-6: ...

Journal: :Epilepsy & Behavior 2011
Silmara Aparecida Faggion Alexandra Olimpio Siqueira Cunha Helene Aparecida Fachim Amanda Salomão Gavin Wagner Ferreira dos Santos Ana Maria Soares Pereira Renê Oliveira Beleboni

Neural mechanisms underlying the onset and maintenance of epileptic seizures involve alterations in inhibitory and/or excitatory neurotransmitter pathways. Thus, the prospecting of novel molecules from natural products that target both inhibition and excitation systems has deserved interest in the rational design of new anticonvulsants. We isolated the alkaloids (+)-erythravine and (+)-11-α-hyd...

Journal: :Pharmacology, biochemistry, and behavior 2008
Vladimir Arkhipov Natalia Kulesskaja Denis Lebedev

Delayed disturbances of cognitive functions caused by intrahippocampal injection of subconvulsive dose of kainic acid were studied in rats. Animals were behaviorally tested for the presence of cognitive deterioration 1 week after bilateral injection of 0.25 microg kainic acid into the left and right hippocampi. Behavioral tests included the retrieval of a food-procuring task, its experimental e...

Journal: :Brain research 1979
P C Emson G Paxinos G Le Gal La Salle Y Ben-Ari A Silver

The origin of the cholinergic innervation to the amygdaloid complex was investigated with the use of acetylcholinesterase (AChE) histochemistry and choline acetyltransferase (ChAT) assay of microdissected nuclei. Visualization of AChE-positive neurones in the ventral forebrain was facilitated by pretreatment of rats with 1.5 mg/kg di-isopropyl phosphofluoridate (DFP). The AChE-positive neurones...

2014
Gisela H. Maia José L. Quesado Joana I. Soares Joana M. do Carmo Pedro A. Andrade José P. Andrade Nikolai V. Lukoyanov

Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life. However, in a subset of rats, kainic acid treatment does not induce overt behaviorally obvious acute SE. The goal of this study was to compare the neuroanatomical and behavioral changes induced by kainate in rats that developed conv...

Journal: :Brain : a journal of neurology 2005
Denise E Fedele Nicolette Gouder Martin Güttinger Laetitia Gabernet Louis Scheurer Thomas Rülicke Florence Crestani Detlev Boison

Adenosine kinase (ADK) is considered to be the key regulator of the brain's endogenous anticonvulsant, adenosine. In adult brain, ADK is primarily expressed in a subpopulation of astrocytes and striking upregulation of ADK in these cells has been associated with astrogliosis after kainic acid-induced status epilepticus (KASE) in the kainic acid mouse model of temporal lobe epilepsy. To investig...

2017
Tobias E. Karlsson Katrin Wellfelt Lars Olson

Inhibition of nerve growth and plasticity in the CNS is to a large part mediated by Nogo-like signaling, now encompassing a plethora of ligands, receptors, co-receptors and modulators. Here we describe the distribution and levels of mRNA encoding 11 key genes involved in Nogo-like signaling (Nogo-A, Oligodendrocyte-Myelin glycoprotein (OMgp), Nogo receptor 1 (NgR1), NgR2, NgR3, Lingo-1, TNF rec...

Journal: :Saudi Journal of Biological Sciences 2021

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