نتایج جستجو برای: k562

تعداد نتایج: 4081  

Fatemeh Rahmani, Maryam Shafagh, Norouz Delirezh

Objective(s): This study focused on determining cytotoxic effects of copper oxide nanoparticles (CuO NPs) on chronic myeloid leukemia (CML) K562 cell line in a cell-specific manner and its possible mechanism of cell death. We investigated the cytotoxicity of CuO NPs against K562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). Materials and Methods: The toxicity w...

2017
Ying Zhou Dongmei He Jinrong Zeng Shijie Bao Jing Lai Yujun Weng Shengting Chen

Objective: The effects of microRNA-20a (miR-20a) antisense oligonucleotides (ASODNs) on the proliferation and apoptosis of K562 cells were investigated, and the effects of these ASODNs in combination with imatinib on K562 cells were preliminarily observed. Methods: miR-20a ASODNs and scrambled oligonucleotides (SODNs) were chemically synthesized, and the later was used as the control. miR-20a A...

2015
Anitha Somanchi Srinivas Somanchi Dean Lee

MicroRNA (miRNA) are non-coding regulatory RNA that are key posttranscriptional regulatory machinery of cells. miRNA play important role in several physiological functions during embryonic development, differentiation, cancer progression as well as hematopoiesis, and regulation of immune responses. miRNA regulate development of various immune cells including T and Natural killer (NK) cells. Owi...

Journal: :Blood 1998
S Motomura T Motoji M Takanashi Y H Wang H Shiozaki I Sugawara E Aikawa A Tomida T Tsuruo N Kanda H Mizoguchi

To overcome the problem of multidrug resistance, we investigated the effectiveness of phosphrothioate antisense oligonucleotides (MDR1-AS) in suppressing multidrug resistance gene (mdr1) expression in drug-resistant acute myelogenous leukemia (AML) blast cells and the K562 adriamycin-resistant cell line K562/ADM. The percentage of cells with the mdr1 gene product P-glycoprotein (P-gp) was decre...

2017
Xiaobo Zhang Yicheng Liu Lu Lu Shaoliang Huang Youxiang Ding Yi Zhang Qinglong Guo Zhiyu Li Li Zhao

Imatinib (IM), as first inhibitor of the oncogenic tyrosine kinase BCR-ABL, has been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. However, resistance to IM usually occurs in CML patients. The bone marrow (BM), as the predominant microenvironment of CML, secretes an abundant amount of cytokines, which may contribute to drug resistance. In current study, we utilized ...

Journal: :International immunology 2001
Z Fishelson I Hochman L E Greene E Eisenberg

The possible participation of hsc70 and hsp70 in cellular protection from complement damage was studied. Human erythroleukemia K562 cells were pretreated with reagents affecting hsc70 or hsp70, and cell sensitivity to lysis by antibody and human complement was examined. Treatment with deoxyspergualin, an hsc70 inhibitor, sensitized K562 cells to complement lysis, whereas treatment with ethanol,...

Journal: :Cancer research 1990
J R Roberts D C Allison R C Donehower E K Rowinsky

The effects of taxol on antitubulin immunofluorescent staining patterns, cellular DNA content, and labeling with [3H]thymidine were measured for the taxol-sensitive HL60 and taxol-resistant K562 cell lines after exposures for 0, 4, 12, and 24 h. Taxol caused a relative increase in the fraction of 4C interphase and metaphase cells in both lines although the 4C interphase accumulation was greater...

Journal: :Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2007
Jun Wu Yanhui Lu Alice Lee Xiaogang Pan Xiaojuan Yang Xiaobin Zhao Robert J Lee

PURPOSE Liposomes co-encapsulating doxorubicin (DOX) and verapamil (VER), and conjugated to transferrin (Tf-L-DOX/VER) were synthesized and evaluated in K562 leukemia cells. The design of this formulation was aimed at selective targeting of tumor cells, reducing cardiotoxicity of DOX and VER, as well as overcoming P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) phenotype. METHODS The...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه ارومیه - دانشکده علوم 1393

یکی از پروتئین های درگیر با سرطان و استرس، گیرنده های بتا آدرنرژیک اند. پروتئین cox-2 نیز فرمی از آنزیم سیکلواکسیژناز (cyclooxygenase) است که توسط فاکتورهای متعددی از جمله التهاب القا شده و با تومورزایی همراه است. فعالیت درمانی بلوکه کننده های بتا مانند پروپرانولول و مهارکننده ی انتخابی cox-2 مانند سلکوکسیب (celecoxib) به ترتیب به بلوکه کردن گیرنده های بتا آدرنرژیک و مهار آنزیم cox-2 نسبت داده ...

2013
Hiroshi Kawada Mitsuyo Kaneko Masakazu Sawanobori Tomoko Uno Hideyuki Matsuzawa Yoshihiko Nakamura Hiromichi Matsushita Kiyoshi Ando

We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H2O2) but not in normal hematopoietic stem/progenitor cells. High AA significantly repressed leukemic cell proliferation as well as neoangiogenesis in immunodeficient mice. W...

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