the public sector is an influential partner of the market economy in many developing countries. in the absence of government’s intervention, economic functioning of these countries could turn into constant disequilibrium without any hope of growth and economic prosperity. on the other hand unlimited government intervention could harm the economic growth by unnatural expansion of public sector a...

Classically it is impossible to have transport without transit, i.e., if the points 1, 2, and 3 lie sequentially along a path then an object moving from 1 to 3 must, at some point in time, be located at 2. For a quantum particle in a three-well system it is possible to transport the particle between wells 1 and 3 such that the probability of finding it at any time in the classically accessible ...

Guanylyl cyclase activating protein 1 (GCAP1), a member of the neuronal calcium sensor (NCS) subclass of the calmodulin superfamily, confers Ca(2+)-sensitive activation of retinal guanylyl cyclase 1 (RetGC1) upon light activation of photoreceptor cells. Here we present NMR assignments and functional analysis to probe Ca(2+)-dependent structural changes in GCAP1 that control activation of RetGC....

We present an elastic model of B-form DNA as a stack of thin, rigid plates or base pairs that are not permitted to deform. The symmetry of DNA and the constraint of plate rigidity limit the number of bulk elastic constants contributing to a macroscopic elasticity theory of DNA to four. We derive an effective twist-stretch energy in terms of the macroscopic stretch ǫ along and relative excess tw...

BACKGROUND Female physician-researchers do not achieve career success at the same rate as men. Differences in nonprofessional responsibilities may partially explain this gap. OBJECTIVE To investigate the division of domestic labor by gender in a motivated group of early-career physician-researchers. DESIGN Nationwide postal survey between 2010 and 2011. SETTING United States. PARTICIPAN...

Linezolid is a new antimicrobial agent effective against drug-resistant gram-positive pathogens which are common causes of infections in hospitalized patients. Many such patients rely on the intravenous or enteral route for nutrition and drug administration. Therefore, the bioavailability of linezolid administered enterally in the presence of enteral feedings in hospitalized patients was examin...

Objective: Laryngeal squamous cell carcinoma is one of the most common malignant tumors in the head and neck region. Due to the poor response to chemotherapeutics in patients and low survival rate, successful treatment of larynx cancer still remains a challenge. Therefore, the identification of novel treatment options is needed. We investigated the anticancer effects of suberoylanilide hydroxam...

Abstract Introduction People initiating treatment for opioid use disorder (OUD) report insomnia to be a high priority, and is associated with compromised OUD outcomes. However, treatments have yet investigated in the clinical setting. Knowledge of prescribing patterns sleep medications among patients an essential first step advance therapeutic development at insomnia-OUD comorbidity. This retro...

Eukaryotic genomes are partitioned into active and inactive domains called euchromatin and heterochromatin, respectively. In Neurospora crassa, heterochromatin formation requires methylation of histone H3 at lysine 9 (H3K9) by the SET domain protein DIM-5. Heterochromatin protein 1 (HP1) reads this mark and directly recruits the DNA methyltransferase, DIM-2. An ectopic H3 gene carrying a substi...

The formation of exciplexes ( non-emitting or poorly emitting ) is proposed as a cause of the deviations of the experimental data from the classical model of excited state electron transfer in polar solvents yielding radical ion pairs. Experimental evidences for the formation of such exciplexes are discussed. Simulation of the dependencies of the quenching rate constant vs. Gibbs energy of elec...