Correction: Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT Baerbel Keller, Irina Zaidman, O. Sascha Yousefi, Dov Hershkovitz, Jerry Stein, Susanne Unger, Kristina Schachtrup, Mikael Sigvardsson, Amir A. Kuperman, Avraham Shaag, Wolfgang W. Schamel, Orly Elpeleg, Klaus Warnatz, and Polina Stepensky Vol. 213, No. 7, June 27, 2016. https://...

A long-lived latent reservoir for HIV-1 persists in CD4+ T cells despite antiretroviral therapy and is the major barrier to cure. In this issue of JEM, Hosmane et al. show that T cell proliferation could explain the long-term persistence of this reservoir.

JEM © The Rockefeller University Press $30.00 Vol. 204, No. 12, November 26, 2007 2773 www.jem.org/cgi/doi/10.1084/jem.20072298 The Rockefeller University Press is pleased to announce that, as of December 2007, all of the content of the Journal of Experimental Medicine will be deposited in PubMed Central. The content will be mirrored on the UK PubMed Central website, and will be freely availabl...

The abundance of supplemental material in The Journal of Experimental Medicine is growing. In the May 2011 issue of JEM, all research papers have a supplement, with an average of 5.9 supplementary items per paper. Only 3 yr ago (May 2008 issue), 16% of JEM papers had no supplementary items, and the overall average was 4.6 items per paper. 3 yr before that (May 2005 issue), 57% of papers had no ...

BACKGROUND Occupational exposures are associated with chronic obstructive pulmonary disease (COPD). This study investigated this association among a population with a high prevalence of tuberculosis and smoking. METHODS Cases (n=110) diagnosed by pulmonologists were selected from specialist respiratory clinics. Frequency sex- and age-matched controls (n=102) were selected from other clinics a...

The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).

95.7% underwent only one or two rounds of external review. No papers endured more than three external review cycles. Our belief is that if we invest additional editorial effort at the point of decision, we can avoid protracted cycles of review and re-review. For example, we neither expect nor require all referees to agree on the merits or deficiencies of every manuscript. When referees disagree...

This issue of JEM presents five articles addressing the issue of manual strangulation in surviving victims of intimate partner violence (IPV). These landmark articles reveal to the medical community what the social services and advocate community has known for a long time: strangulation, or throttling, is a common means of domestic violence inflicted upon victims by their perpetrators. © 2001 E...

In this issue of JEM, Chan et al. describe a novel way by which an investigational form of chemotherapy known as low-dose metronomic chemotherapy can inhibit tumor growth, which also has therapeutic implications for targeting tumor-initiating cells (TICs), the tumor stroma, and chemokine receptors, as well as invasion and metastasis.

In this issue Ohsaki et al. (https://doi.org/10.1084/jem.20171163) explain how breastfeeding can prevent the onset of food allergies in offspring by instructing T reg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake of allergen-containing IgG immune complexes (Ig-ICs) by gut dendritic cells (DCs).