The IjB kinase (IKK) complex is the signal integration hub for NF-jB activation. Composed of two serine-threonine kinases (IKKa and IKKb) and the regulatory subunit NEMO (also known as IKKc), the IKK complex integrates signals from all NF-jB activating stimuli to catalyze the phosphorylation of various IjB and NF-jB proteins, as well as of other substrates. Since the discovery of the IKK comple...

There are two neutral B 0 {B 0 meson systems, B 0 d {B 0 d and B 0 s {B 0 s (generically denoted B 0 q {B 0 q , q = s; d), which exhibit the phenomenon of particle-antiparticle mixing 1]. Such a system is produced in one of its two possible states of well-deened avor: jB 0 i (bq) or jB 0 i (bq). Due to avor-changing interactions, this initial state evolves into a time-dependent quantum superpos...

In the last twenty years, a theory of real Jordan triples has been developed. In 1994 T. Dang and B. Russo introduced the concept of J∗B–triple. These J∗B–triples include real C∗–algebras and complex JB∗–triples. However, concerning J∗B–triples, an important problem was left open. Indeed, the question was whether the complexification of a J∗B–triple is a complex JB∗–triple in some norm extendin...

1. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, et al. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Clin Chem 2003;49:1–6. 2. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, et al. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clin Chem 2003;49:7–18...

The nucleotide sequence of the genomic RNA of kennedya yellow mosaic tymovirus-Jervis Bay isolate (KYMV-JB) has been determined. The genome of KYMV-JB is 6362 nucleotide residues long and encodes three major open reading frames. The genomic organization and the encoded proteins of KYMV-JB are very similar to those of three other tymoviruses that have recently been reported. Sequence comparisons...

In 1987 Drinfeld [Dr2] gave an extremely important realization of quantum affine algebras [Dr1][Jb]. This new realization has lead to numerous applications such as the vertex representations [FJ][J]. The proof of this realization was not in print until Beck’s braid group interpretation for the untwisted types [B]. Some of lower rank cases were also studied in [D][S]. All these work started from...

After introducing double derivations of $n$-Lie algebra $L$ we‎ ‎describe the relationship between the algebra $mathcal D(L)$ of double derivations and the usual‎ ‎derivation Lie algebra $mathcal Der(L)$‎. ‎In particular‎, ‎we prove that the inner derivation algebra $ad(L)$‎ ‎is an ideal of the double derivation algebra $mathcal D(L)$; we also show that if $L$ is a perfect $n$-Lie algebra‎ ‎wit...

Previously, a series of clonal alloantigen-dependent T cell lines established from the channel catfish revealed distinctly different TCR beta rearrangements. Here, a follow-up study of the junctional diversity of these TCR gene rearrangements focuses on characterization of the genomic organization of the TCRB locus. Surprisingly, a total of 29 JB genes and two substantially different CB genes w...

Diosgenin, a steroidal saponin present in fenugreek (Trigonella foenum graecum) and other plants, has been shown to suppress inflammation, inhibit proliferation, and induce apoptosis in a variety of tumor cells, but through a mechanism that is poorly understood. In the present study, we report that diosgenin inhibits receptor-activated nuclear factor-kappaB ligand-induced osteoclastogenesis, su...

Viral infection or TLR3 engagement causes activation of the transcription factors IRF-3 and NF-jB, which collaborate to induce transcription of type I IFN genes. IKKe and TBK1 are two IKK-related kinases critically involved in virusand TLR3-triggered activation of IRF-3. We identified a protein termed SIKE (for Suppressor of IKKe) that interacts with IKKe and TBK1. SIKE is associated with TBK1 ...